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LeadershipI think that the phrase ‘creative productivity’ captures the essence of an organic chemist’s work. It’s not about the number of new molecules produced per day at all. Creative organic chemists have much more in common with prolific artists and craftspeople. Prolific chemists are relentless discoverers of synthetic pathways that result in a stream of new molecules in, for example, pharmaceutical research. Being prolific involves dealing with the complexities of synthetic pathways, completing projects, and strategizing the next steps once the SAR study results are in. Increasing productivity involves knowledge, and applying it, using the right tools.
Acquire knowledge
Becoming more knowledgeable by acquiring a deeper insight into techniques such as flash column chromatography will improve your productivity. For example, we have a blog where you can find answers to questions such as, “What is the best way to purify an amine?” and “What exactly is a column volume?”. Sources of information like these will help increase your knowledge and the productivity of your column chromatography methods.
Use the right flash purification tools
When faced with challenging separations, chemists often use over-sized columns because they think they need a much bigger column to ensure a successful purification. But how much bigger is usually an educated guess. What if you could confidently choose the column size and capacity?
The educated guess approach is no match for the confidence you can have when you know that you have chosen the correct sized column. How much more productive would you be if you could use flash chromatography columns that are half the size you are using now? As we will see later, this is perfectly possible providing you have the right tools. Similarly, how would your work be affected if you used half as much of everything and still routinely and confidently produced pure compounds? What if you needed to load only half the volume of solvent into your rotary evaporator? What impact would it have on the size of glassware you use? When the optimal column, a smaller column, is used, fractions are more concentrated. Would it be beneficial if the collected fractions were more concentrated? Analyze the possibilities and find the right purification tool for the job.
Enable the use of alternative solvents
Find the optimal synthetic pathway
A new system to boost your discovery chemistry
The new Biotage Selekt® system improves on our patented column size recommendation intelligence to provide you with the information you need to choose the right sized column. Advanced background correction enables you to incorporate alternative solvents such as acetone. Added to that, Biotage Selekt is a two-channel system that can quickly change conditions from normal to reversed phase solvents to immediately deal with challenging separations without having to go to a separate instrument.
