Biotage offers a range of products for reaction mixture work-up and preparation of organic extracts.
A complete set of tools to speed up traditional work flow processes and also enhance productivity and flexibility in the laboratory. These products range from solid supported reagents and scavengers, including the market leading Biotage Metal Scavengers, through to laboratory essentials, such as tubes, frits and separators, which can improve even the simplest of procedures.
The offer of work-up products spans over a range of techniques and also address throughput requirements from filtration, catch & release, and scavenging cartridges in organic synthesis workflows.
Catch & Release and Scavenging of Basic Compounds
ISOLUTE® SCX-2 is a silica-based media with a chemically bonded propylsulfonic acid functional group. It is used for the isolation of
a wide range of basic compounds using both catch & release and scavenging protocols. ISOLUTE SCX-2 is available packed into SPE
cartridges for flow-through. Using the catch & release approach, basic target compounds can be isolated from a range of reaction mixtures. ISOLUTE SCX-2 cartridges can be used to remove excess basic reagents, allowing neutral or acidic compounds to pass straight through to the collection vessel.
Catch & Release and Scavenging of Acidic Compounds
ISOLUTE® PE-AX is a silica-based sorbent with a chemically bonded quaternary amine functional group. It is used for the isolation of a wide range of acidic compounds using both catch & release and scavenging protocols. ISOLUTE PE-AX is available packed into SPE cartridges for flow-through. Using the catch &
release approach, acidic target compounds can be isolated from a range of reaction mixtures. ISOLUTE PE-AX cartridges can be
used in a scavenging mode to remove excess acidic reagents, allowing neutral or basic compounds to pass straight through to the collection vessel.
Simultaneous Scavenging of Basic and Acidic Compounds
ISOLUTE® PE-AX/SCX-2 is a silica-based media with chemically bonded propylsulfonic acid and quaternary amine functional groups. It is used for the isolation of a wide range of neutral compounds. ISOLUTE PE-AX/SCX-2 is available packed into SPE cartridges flow-through.
Concentration of Prep-LC Fractions Using Catch & Release
ISOLUTE® 103 is a hydroxylated polystyrene divinylbenzene co-polymer. The resin is used for the isolation of a wide range of compounds from prep LC fractions using catch & release protocol. The approach replaces the need for time-consuming evaporation of aqueous based fractions.
Synthetic organic chemistry is the genesis of new pharmaceutical and commercial chemical products. In short, it is based on the idea that two or more carbon-based compounds can be forced to react using heat, or other energy source, to create a new, novel product – but this we already know.
What are the steps most chemists follow to do this successfully?
The offer of work-up products spans over a range of techniques and also address throughput requirements from filtration, catch & release, and scavenging cartridges in organic synthesis workflows.
ISOLUTE® Phase Separators are used to separate aqueous and chlorinated solvents following liquid-liquid extraction. The proprietary filtration device allows the flow of the organic solvent but holds up the aqueous layer (for up to 24 hours).
Sodium sulfate is commonly used for drying water-immiscible organic solvents. ISOLUTE® Sodium Sulfate Drying Cartridges are a convenient alternative to using the bulk material. The male/female Luer design
allows the cartridge to be placed in-line after the main work-up cartridge. Alternatively, connect to an empty reservoir and load larger volumes of solvent. No need to use additional equipment. Just plug in and filter for instant results. The cartridge contains 2.5 g sodium sulfate and can remove up to 3.5 mL water.
Celite* cartridges are used as a filtration device for removal of “tar” and particulate materials (e.g. catalysts, as first- stage work-up following organic synthesis). The cartridges contain an inert Celite material, a modified diatomaceous earth, with an optimized particle-size distribution for flow-through processing. The cartridge holds up catalysts such as insoluble metal oxides and Pd/C, providing filtrates for subsequent work-up. The retention of the catalyst in a cartridge format minimizes safety issues and cross-contamination, a common problem when the catalyst is captured in an open filtration device such as a sintered funnel.
*Celite is a trademark owned by Johns-Manville Corporation
ISOLUTE® HM-N is a modified form of diatomaceous earth. The support has many uses in reaction work-up, including:
Synthetic organic chemistry is the genesis of new pharmaceutical and commercial chemical products. In short, it is based on the idea that two or more carbon-based compounds can be forced to react using heat, or other energy source, to create a new, novel product – but this we already know.
What are the steps most chemists follow to do this successfully?
Part No. | Description | Pack Size | List Price | |
---|---|---|---|---|
120-1151-D | 15 mL Frit Inserter | 5 | 62 USD | Add to quote/cart |
120-1151-J | 150 mL Frit Inserter | 1 | 29 USD | Add to quote/cart |
120-1151-E | 25 mL Frit Inserter | 1 | 28 USD | Add to quote/cart |
120-1151-F | 70 mL Frit Inserter | 1 | 28 USD | Add to quote/cart |
122-2100 | Biotage® FlashVac rack special | 1 | Add to quote/cart | |
122-0030 | Biotage® FlashVac silicone lid gasket | 1 | 37 USD | Add to quote/cart |
122-1030 | Biotage® FlashVac-10 19 mm rack | 1 | 264 USD | Add to quote/cart |
122-0049 | Biotage® FlashVac-10 and -20 glass tank | 1 | 305 USD | Add to quote/cart |
122-0044 | Biotage® FlashVac-10 and -20 rack handle | 1 | 21 USD | Add to quote/cart |
122-0047 | Biotage® FlashVac-10 lid | 1 | 1102 USD | Add to quote/cart |
122-1034 | Biotage® FlashVac-10 rack for 25 mm tubes | 1 | 243 USD | Add to quote/cart |
122-1036 | Biotage® FlashVac-10 Top/Mid PLATE, 25 mm | 1 | 105 USD | Add to quote/cart |
122-1019 | Biotage® FlashVac-10 with 19 mm 10 Position rack | 1 | 1528 USD | Add to quote/cart |
122-1025 | Biotage® FlashVac-10, 10 Ports with 25 mm rack | 1 | 1622 USD | Add to quote/cart |
122-2061 | Biotage® FlashVac-20 19 mm rack | 1 | 278 USD | Add to quote/cart |
122-2062 | Biotage® FlashVac-20 25mm rack | 1 | 264 USD | Add to quote/cart |
122-0048 | Biotage® FlashVac-20 lid, complete | 1 | 1102 USD | Add to quote/cart |
122-2019 | Biotage® FlashVac-20 with 19mm 20 position rack | 1 | 1528 USD | Add to quote/cart |
122-2025 | Biotage® FlashVac-20 with 25mm 10 position rack | 1 | 1528 USD | Add to quote/cart |
123-2016 | Biotage® Gravity rack with 16 mm collection tube rack | 1 | 667 USD | Add to quote/cart |
123-2019 | Biotage® Gravity rack with 19 mm collection tube rack | 1 | 667 USD | Add to quote/cart |
123-2119 | Biotage® Gravity Rack, TOP/MID plate, 19 mm | 1 | 111 USD | Add to quote/cart |
810-0100-D | Celite 545 1 g/15 mL | 20 | 111 USD | Add to quote/cart |
810-0100-C | Celite 545 1 g/6 mL | 30 | 133 USD | Add to quote/cart |
810-0100-CG | Celite 545 1 g/6 mL (Tabless) | 30 | 147 USD | Add to quote/cart |
810-1000-J | Celite 545 10 g/150 mL | 8 | 105 USD | Add to quote/cart |
810-0250-E | Celite 545 2.5 g/25 mL | 20 | 139 USD | Add to quote/cart |
810-0045-P01 | Celite 545 45 mg plate | 1 | 188 USD | Add to quote/cart |
120-1110 | Flash Luer Lock to Luer Adapters | 25 | 49 USD | Add to quote/cart |
103-0200-E | ISOLUTE® 103 2 g/25 mL | 20 | 694 USD | Add to quote/cart |
103-0020-BG | ISOLUTE® 103 200 mg/3 mL (Tabless) | 50 | 312 USD | Add to quote/cart |
103-0020-C | ISOLUTE® 103 200 mg/6 mL | 30 | 166 USD | Add to quote/cart |
103-0020-CG | ISOLUTE® 103 200 mg/6 mL (Tabless) | 30 | 182 USD | Add to quote/cart |
103-0500-E | ISOLUTE® 103 5 g/25 mL | 20 | 1671 USD | Add to quote/cart |
103-0050-C | ISOLUTE® 103 500 mg/6 mL | 30 | 319 USD | Add to quote/cart |
103-0050-CG | ISOLUTE® 103 500 mg/6 mL (Tabless) | 30 | 332 USD | Add to quote/cart |
180-0300-P01 | ISOLUTE® 96 Si-Thiol 300 mg plate | 1 | 438 USD | Add to quote/cart |
121-9650 | ISOLUTE® Array 24 | 1 | 193 USD | Add to quote/cart |
121-9660 | ISOLUTE® Array 24 Sealing Caps | 50 | 21 USD | Add to quote/cart |
120-1920-T | ISOLUTE® ARRAY Phase separator loose wells 2 mL | 100 | 139 USD | Add to quote/cart |
120-1920-TP | ISOLUTE® ARRAY PHASE SEPARATOR PLATE 2ML | 1 | 182 USD | Add to quote/cart |
420-5000-J | ISOLUTE® CN 50 g/150 mL | 8 | 961 USD | Add to quote/cart |
420-7000-J | ISOLUTE® CN 70 g/150 mL | 8 | 1244 USD | Add to quote/cart |
120-1106 | ISOLUTE® Column Adapter 150 mL columns | 5 | 209 USD | Add to quote/cart |
120-1215-D | ISOLUTE® Double Fritted Reservoir (SG), 15 mL 20 µm PE | 100 | 182 USD | Add to quote/cart |
120-1218-J | ISOLUTE® Double Fritted Reservoir (SG), 150 mL 20 µm PE | 25 | 182 USD | Add to quote/cart |
120-1217-F | ISOLUTE® Double Fritted Reservoir (SG), 70 mL 20 µm PE | 50 | 117 USD | Add to quote/cart |
120-1120-K | ISOLUTE® Filtration Column 50 mL | 25 | 193 USD | Add to quote/cart |
456-1000-F | ISOLUTE® FLASH SCX-2 10 g/70 mL | 16 | 442 USD | Add to quote/cart |
456-0100-C | ISOLUTE® FLASH SCX-2 1g/6ml | 30 | 175 USD | Add to quote/cart |
456-0200-D | ISOLUTE® FLASH SCX-2 2 g/15 mL | 20 | 175 USD | Add to quote/cart |
456-0200-DG | ISOLUTE® FLASH SCX-2 2 g/15 mL | 20 | 209 USD | Add to quote/cart |
456-2000-F | ISOLUTE® FLASH SCX-2 20 g/70 mL | 16 | 874 USD | Add to quote/cart |
456-2500-J | ISOLUTE® FLASH SCX-2 25 g/150 mL | 8 | 535 USD | Add to quote/cart |
456-0500-E | ISOLUTE® FLASH SCX-2 5 g/25 mL | 20 | 312 USD | Add to quote/cart |
456-5000-J | ISOLUTE® FLASH SCX-2 50 g/150 mL | 8 | 1054 USD | Add to quote/cart |
456-0050-B | ISOLUTE® FLASH SCX-2 500 mg/3 mL | 50 | 193 USD | Add to quote/cart |
456-7000-J | ISOLUTE® FLASH SCX-2 70 g/150 mL | 8 | 1469 USD | Add to quote/cart |
120-1365-D | ISOLUTE® Fritted Reservoir (SG), 15 mL 10 µm PE | 100 | 166 USD | Add to quote/cart |
120-1385-D | ISOLUTE® Fritted Reservoir (SG), 15 mL 10 µm PTFE | 100 | 261 USD | Add to quote/cart |
120-1115-D | ISOLUTE® Fritted Reservoir (SG), 15 mL 20 µm PE | 100 | 160 USD | Add to quote/cart |
120-1375-D | ISOLUTE® Fritted Reservoir (SG), 15 mL 20 µm PTFE | 100 | 292 USD | Add to quote/cart |
120-1369-J | ISOLUTE® Fritted Reservoir (SG), 150 mL 10 µm PE | 25 | 230 USD | Add to quote/cart |
120-1119-J | ISOLUTE® Fritted Reservoir (SG), 150 mL 20 µm PE | 25 | 182 USD | Add to quote/cart |
120-1366-E | ISOLUTE® Fritted Reservoir (SG), 25 mL 10 µm PE | 100 | 230 USD | Add to quote/cart |
120-1386-E | ISOLUTE® Fritted Reservoir (SG), 25 mL 10 µm PTFE | 100 | Add to quote/cart | |
120-1116-E | ISOLUTE® Fritted Reservoir (SG), 25 mL 20 µm PE | 100 | 193 USD | Add to quote/cart |
120-1376-E | ISOLUTE® Fritted Reservoir (SG), 25 mL 20 µm PTFE | 100 | 383 USD | Add to quote/cart |
120-1396-E | ISOLUTE® Fritted Reservoir (SG), 25 mL 5 µm PTFE | 100 | 388 USD | Add to quote/cart |
120-1367-F | ISOLUTE® Fritted Reservoir (SG), 70 mL 10 µm PE | 50 | 139 USD | Add to quote/cart |
120-1387-F | ISOLUTE® Fritted Reservoir (SG), 70 mL 10 µm PTFE | 50 | 249 USD | Add to quote/cart |
120-1118-F | ISOLUTE® Fritted Reservoir (SG), 70 mL 20 µm PE | 50 | 117 USD | Add to quote/cart |
120-1377-F | ISOLUTE® Fritted Reservoir (SG), 70 mL 20 µm PTFE | 50 | 319 USD | Add to quote/cart |
120-1397-F | ISOLUTE® Fritted Reservoir (SG), 70 mL 5 µm PTFE | 50 | 293 USD | Add to quote/cart |
801-1000-J | ISOLUTE® MgS04 10 g/150 mL | 8 | 102 USD | Add to quote/cart |
802-0250-D | ISOLUTE® NA2S04 2.5g/15 mL | 20 | 133 USD | Add to quote/cart |
503-1000-F | ISOLUTE® PE-AX 10 g/ 70 mL | 16 | 511 USD | Add to quote/cart |
503-0200-D | ISOLUTE® PE-AX 2 g/15 mL | 20 | 200 USD | Add to quote/cart |
503-2000-F | ISOLUTE® PE-AX 20 g/ 70 mL | 16 | 1026 USD | Add to quote/cart |
503-0500-E | ISOLUTE® PE-AX 5 g/25 mL | 20 | 312 USD | Add to quote/cart |
988-1000-F | ISOLUTE® PE-AX/SCX-2 10 /70 mL | 16 | 887 USD | Add to quote/cart |
988-2000-F | ISOLUTE® PE-AX/SCX-2 20 g/70 mL | 16 | 1715 USD | Add to quote/cart |
988-0500-E | ISOLUTE® PE-AX/SCX-2 5 g/25 mL | 20 | 575 USD | Add to quote/cart |
120-1906-D | ISOLUTE® Phase separator 15 mL | 100 | 223 USD | Add to quote/cart |
120-1909-J | ISOLUTE® Phase separator 150 mL | 25 | 236 USD | Add to quote/cart |
120-1903-B | ISOLUTE® Phase separator 3 mL | 100 | 182 USD | Add to quote/cart |
120-1903-BG | ISOLUTE® Phase separator 3 mL tabless | 100 | 188 USD | Add to quote/cart |
120-1905-CG | ISOLUTE® Phase separator 6 mL tabless | 100 | 243 USD | Add to quote/cart |
120-1907-E | ISOLUTE® Phase separator column 25 mL | 100 | 292 USD | Add to quote/cart |
120-1905-C | ISOLUTE® Phase separator column 6 mL | 100 | 223 USD | Add to quote/cart |
120-1910-P05 | ISOLUTE® Phase separator plate, fixed well | 5 | 437 USD | Add to quote/cart |
120-1910-P01 | ISOLUTE® PHASE SEPARATOR PLATE,FIXED WELL | 1 | 105 USD | Add to quote/cart |
120-1901-A | ISOLUTE® Phase separator, 1 mL | 100 | 152 USD | Add to quote/cart |
120-1908-F | ISOLUTE® Phase separator, 70 mL | 50 | 188 USD | Add to quote/cart |
120-1106-D | ISOLUTE® Reservoir (SG) 15 mL | 100 | 90 USD | Add to quote/cart |
120-1110-J | ISOLUTE® Reservoir (SG) 150 mL | 25 | 117 USD | Add to quote/cart |
120-1107-E | ISOLUTE® Reservoir (SG) 25 mL | 100 | 111 USD | Add to quote/cart |
120-1109-F | ISOLUTE® Reservoir (SG) 70 mL | 50 | 77 USD | Add to quote/cart |
532-1000-F | ISOLUTE® SCX-2 10 g/70 mL | 16 | 486 USD | Add to quote/cart |
532-0200-D | ISOLUTE® SCX-2 2 g/15 mL | 20 | 188 USD | Add to quote/cart |
FlashVac Sample Processing Manifolds are used to process the complete range of ISOLUTE work-up columns. The manifolds can be used for Catch & Release and scavenging SPE, filtration, and off-line sample loading prior to flash chromatography.
Biotage offers a range of accessories for use with filtration, Catch & Release, and scavenging SPE columns in organic synthesis work-up schemes.
Accessories include stop-cocks, luer tip caps, cartridge adaptors.
Biotage is the Global Go-To Separations Company, supporting customers from drug discovery and development through to diagnostics and analytical testing with intelligent and sustainable workflow solutions. Our expertise and top-tier separation solutions play a key role in streamlining our customers’ workflows and improving their outcomes. Headquartered in Sweden, Biotage operates globally with 700 employees, serving over 80 countries. Our company is listed on NASDAQ Stockholm (BIOT).
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