ISOLUTE® SCX-2 belongs to a class of strong supported acids. As a bound sulfonic acid, it has a natural propensity to bind alkali and some transition metal group metals, which means that it can be used as a scavenger for metals with a +I or +II oxidation state, such as Na, K, Li, also Pd, Rh, and Ru. Since SCX-2 is acidic in nature, it is typically used as a metal scavenger when the target product is not basic, to avoid the obvious acid/base product binding interactions with the scavenger.
For over 15 years Biotage has been guiding and leading the industry in metal scavenging and is the number 1 choice for processes worldwide. Clean, effective, simple and specific metal scavengers allow you to remove metal impurities whilst maximizing product recovery.
More effective than traditional methods, less energy intensive than distillation, less API loss compared to carbon, less time and risk of failed batches than recrystallization, operationally simple and designed for plug and play approaches, in fixed beds or batch stirring applications.
Key supplier to industry for over 20 years, used in numerous patents and cGMP process campaigns
From grams in research through to multi kilogram quantities in production campaigns
Lot control, QA / QC documentation, SDS, ISO 9001 / 14001 registration, BSE / TSE statement, shelf-life statement
Part No. | Description | Pack Size | List Price | |
---|---|---|---|---|
9536-1000 | ISOLUTE® Si-Propylsulfonic Acid (SCX-2), 1 kg | 1 | 3002 USD | Add to quote/cart |
9536-0010 | ISOLUTE® Si-Propylsulfonic Acid (SCX-2), 10 g | 1 | 78 USD | Add to quote/cart |
9536-0100 | ISOLUTE® Si-Propylsulfonic Acid (SCX-2), 100 g | 1 | 326 USD | Add to quote/cart |
9536-0025 | ISOLUTE® Si-Propylsulfonic Acid (SCX-2), 25 g | 1 | 143 USD | Add to quote/cart |
9536-0500 | ISOLUTE® Si-Propylsulfonic Acid (SCX-2), 500 g | 1 | 1700 USD | Add to quote/cart |
K-MS-3 | Metal Scavenging Screening Kit - SPE | 1 | 179 USD | Add to quote/cart |
K-MS-2 | Metal Scavenging Toolkit - Batch | 1 | 471 USD | Add to quote/cart |
This note highlights key issues and perspectives relating to the successful use of metal scavengers in pharma, under ICH Q3D
Next to palladium, ruthenium is the next most frequently used metal. It is much more difficult to remove from reactions. This poster highlights methods and approaches towards ruthenium mitigation.
This poster highlights advantages and helps to identify potential pitfalls associated with the application of metal scavengers in scale up and process SOPs.
Metal scavengers are a clean and very effective way to remove metal residues from reaction products at trace levels. Perfect for any chemical laboratory working in regulated environments. Product Manager Sunil Rana, Ph.D., gives the metal scavenger tour in this video.
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Biotage is the Global Go-To Separations Company, supporting customers from drug discovery and development through to diagnostics and analytical testing with intelligent and sustainable workflow solutions. Our expertise and top-tier separation solutions play a key role in streamlining our customers’ workflows and improving their outcomes. Headquartered in Sweden, Biotage operates globally with 700 employees, serving over 80 countries. Our company is listed on NASDAQ Stockholm (BIOT).
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