Coupling Agent for Amide and Ester Synthesis, Formation of Pentafluorophenyl (PFP) and Other Activated Esters
Biotage® PS-Carbodiimide is a neutral, bound carbodiimide that can be used for the synthesis of amides and esters. In general, PS-Carbodiimide was found to synthesize amides in high yield and purity without evidence of residual amine or carboxylic acid. Unreacted carboxylic acid, normally used in excess relative to the amine, remains bound to the resin during workup.
Supported HOBt Esters, fast access to High Purity Amide Product
Biotage® PS-HOBt(HL) is a sulfonamide-linked, polymer supported equivalent of 1-hydroxybenzotriazole (HOBt). PS-HOBt(HL) is used to generate bound HOBt active esters, which can either be made and used in situ, or isolated and stored as stable intermediates for the synthesis of high purity amides.
Biotage® PS-Isocyanate can readily scavenge excess nucleophiles, which are often used to drive reactions to completion. The reaction of nucleophiles with the isocyanate moiety occurs without liberation of small molecule by-products.
Biotage® PS-PPh3-Pd resin is a polystyrene-supported equivalent of the small molecule catalyst tetrakis(triphenylphosphine) palladium(0) [Pd(Ph3P)4]. The primary application for the resin is as a catalyst for Suzuki-Miyaura coupling reactions between arylboronic acids and aryl halides. PS-PPh3-Pd may also have applications in other types of palladium-catalyzed processes in which Pd(Ph3P)4 is used. The Suzuki reaction is one of the most widely practiced coupling protocols for the preparation of symmetrical and unsymmetrical biaryl compounds. The resin was developed to perform in a manner similar to that of the well-established catalyst, while facilitating reagent handling and simplifying workup, product isolation, and removal of palladium.
Powerful Non-nucleophilic Guanidine Base for Alkyation and C-C Bond Formation
Biotage® PS-TBD is a polymer-supported bicyclic guanidine moiety (1,5,7-triazabicyclo[4.4.0]dec-5-ene) base. PS-TBD applications include alkylation of phenols and amines; esterification of carboxylic acids using alkyl halides; alkylation of activated methylene compounds; de-halogenation of organic halides; high throughput synthesis of aryl triflates and aryl nonaflates, and the regioselective synthesis of lysophospholipids.
Self-Indicating TEMPO Oxidation, Reusable and No Work-up Required
Biotage® PS-TEMPO is a novel polymer bound oxidant, based on a polystyrene bound, sulfonic ester linked 2,2,6,6-tetramethylpiperidine-1-oxyl species (PS-TEMPO),. It allows rapid and efficient access to often unstable ketone or aldehyde reactive species, and displays a visual indication of its oxidation state. The color change observed as the oxidation state of the reagent changes, can give an indication of the extent to which the reagent has been used. PS-TEMPO can be regenerated and reused for multiple oxidation reactions.
Easy to Remove Phosphine Oxide for Mitsunobu/Wittig Reaction
Biotage® PS-Triphenylphosphine is a powerful supported phosphine reagent for popular reactions such as Wittig, Mitsunobu, chlorination of acids and alcohols and the scavenging of alkyl halides. Unlike the small molecule reagent, the triphenylphosphine oxide by-product of reaction stays 100% resin bound, meaning that removal of product from phosphine oxide can be accomplished by simple low tech filtration techniques.
Automation for Microwave Assisted Organic Synthesis
Biotage® Initiator+ can be upgraded from a single-sample manual format to an automated 8- or 60-position system. The modular design allows a user to add on different automated sample processors dependent on throughput requirements.
Sfär is the Swedish word for "sphere", and the name of our columns reflects the fact that we have made spherical silica a standard due to its higher surface area and higher loading capacity. Reliable and flexible, Biotage® Sfär columns deliver larger loading capacities, tighter elution bands and purer fractions than traditional flash columns.
Biotage® SNAP Bio flash cartridges were developed with a small particle size (20 μm) and large pore size (300 Å) to provide increased resolution and the effective separation of complex peptide mixtures.
Reversed-phase flash chromatography is a very effective purification technique. Its main application areas include polar, ionizable and highly lipophilic compounds which cannot easily be separated by normal-phase techniques.
Biotage® KP-NH chemistry shields synthetic organic amines from acidic silanols providing improved selectivity, peak shape, purity and yield. Unlike traditional silica and 1° amine (propyl amine) bonded silica, Biotage KP-NH doesn’t require the use of chlorinated solvents or amine additives.
Biotage SNAP Ultra flash chromatography cartridges deliver the highest purification performance available. Packed with Biotage® HP-Sphere™ spherical silica, these cartridges have the highest loading capacity, lowest backpressure and can withstand high flow rates.