ISOLUTE® Si-Thiol
Metal scavenger
Diverse metal scavenger suitable for a wide range of applications including scavenging of metals used in organic chemistry like Pd, Pt, Cu, Hg, Ag and Pb.
ISOLUTE® Si-Thiol is the silica-bound equivalent of 1-propanethiol which is primarily used in the pharmaceutical industry as a metal scavenger for metals such as Pd, Pt, Cu, Hg, Ag and Pb. It can also be useful for covalent scavenging of alkyl, benzyl and allyl halides as well as a variety of other electrophiles including acid chlorides and isocyanates.
With lot control, QA/QC documentation, SDS, ISO 9001/14001 registration, BSE/TSE statement and shelf-life statement, ISOLUTE® Si-Thiol also supports the audit trail.
Specifications
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Chemical name
Silica 1-propanethiol; 3-Mercaptopropyl silica gel (Si-Thiol; Si-SH)
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Resin type
Bioanalytical grade silica
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Application
Metal scavenger (e.g., Pd, Pt, Cu, Hg, Ag and Pb), scavenger of electrophiles eg. alkyl-, benzyl- and allyl- halides, acid chlorides, isocyanates
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Typical scavenging conditions
Add 3-5 equiv. Stir for 15 min-2 h, then filter, also amenable to fixed bed metal scavenging approaches
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Compatible solvents
Methanol (MeOH), Dichloromethane (DCM), Acetonitrile (MeCN), Acetone, Ethyl Acetate (EtOAc), N,N-Dimethylformamide (DMF), Dimethylsulfoxide (DMSO)
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Storage
Cool, dry location
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Shelf-life / retest date
5 years / typically annually thereafter depending on process
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Capacity
1.3 mmol/g
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Particle size
40-60 microns
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Bulk density
700g /L
Resources
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Download
Product note
ISOLUTE® Si-TMT metal scavenger
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Download
Poster
New applications of ruthenium scavenging
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Download
Poster
Metal scavengers in process chemistry: An investigative study
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Read article
Application note
Metal scavengers: metal mitigation, extractables and regulatory perspectives
Ordering information
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