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Isolera™ Spektra LS

Simply efficient: purify 1 g-150 g sample

Flash Purification System Isolera Spektra LS
Flash Purification System Isolera Spektra LS_Front Page Flash Chromatography System Isolera Spektra LS Biotage Isolera LS DLV-500 DLV-500 Flash chromatography system Isolera LS DLV-500 DLV-500

Biotage(R) Isolera LS is the definitive flash chromatography system for reliable scaling up from grams to to multi, even hundred gram scale purification, using the industry standard original Isolera interface. Enjoy all of the sophisticated software features of laboratory scale systems in a robust instrument built for scale-up labs. Isolera Spektra LS adds an integrated pump assisted loading mechanism for larger samples, and a funnel rack collection option which allows samples to be collected in larger fraction collection vessels.

Isolera™ Spektra LS flash systems are automated purification systems designed to purify synthesis reaction mixtures, natural product extracts, and other organic compound mixtures from gram to multi-gram quantities.

Achieve up to 30% solvent savings with Gradient Optimization “GO”

Step-gradients can be short and powerful providing separations for one or more compounds but can be challenging to develop and optimize. Isolera Spektra provides gradient optimization through new, patent-pending TLC-to-Step Gradient technology. Using solvent and TLC Rf values, Isolera Spektra builds a gradient to separate all the compounds (up to 6) in the sample. This new technology will also provide cartridge selection guidance based on the cartridge loading capacity and purification speed. The step gradient can also be used to isolate a targeted compound reducing run time and solvent use further.

Improve fraction and compound purity with λ-All detection and PDA spectral analysis

New PDA scanning and λ-All technology detects any UV absorbing compound eluting from a flash cartridge while measuring and displaying each eluting compound’s individualUV spectrum. Combined with novel baseline rise correction,yield losses to improper wavelength selection and large fraction volumes are no longer a concern. The PDA spectra can be reviewed and used to determine fraction purity eliminating the need for post-flash purity analysis.

Elute complex samples with the Quatro-binary gradient

Use up to four solvents in a single gradient to easily purify samples with diverse polarity. With Quatro-binary gradient capability traditional binary gradients with a limited polarity range can be adjusted to elute very lipophilic and highly polar compounds within a single purification.Or compound solubility during the separation by adding a constant amount of a co-solvent, acid, or base with the Isolera advanced pump.

Maintain compound solubility with a ternary co-solvent

Isocratically pump a third solvent into any binary gradient to help maintain compound solubility eliminating potential over-pressure issues caused by precipitating compounds.

Enhance productivity with on-the-fly editing

Isolera™ methods can easily be edited either in front of the Isolera or from the comfort of your office. Edit the gradient (click & drag points AND segments), flow rate, collection volume, fraction wavelengths and modes, and add more collection racks if you need to – all while the run is in progress. Gradient changes can now be made with a simplified graphical interface or through a table layout.

Achieve superior purification with Biotage flash cartridges

The Isolera™ Spektra LS systems can use various styles including all Biotage® SNAP family and Biotage® SFAR, with bed masses from 50 to 1500 g.

INSTRUMENTS

Part No. Description Product type Pack Size Price
ISO-1LSW ISO-1LSV Isolera™ LS, One Channel, Extended Collection Bed, 200-400 nm Detector Instruments 1 Log in for price
ISO-1LSW ISO-1LSW Isolera™ LS, One Channel, Extended Collection Bed, 200-800 nm UV-VIS Detector Instruments 1 Log in for price

CONSUMABLES

Part No. Description Product type Pack Size Price
DLV-505 Empty dry load cartridges and frits, 4/cs Consumables 4 Log in for price
DLV-TF Top frit for DLV-500 Consumables 10 Log in for price
FSK0-1107-0750 FSK0-1107-0750 Biotage® SNAP KP-SIL 750 g, 2/cs Consumables 2 Log in for price
FSK0-1107-1500 FSK0-1107-1500 Biotage® SNAP KP-SIL 1500 g, 2/cs Consumables 2 Log in for price
FSL0-1118-0950 Biotage® SNAP KP-C18-HS 950 g, 1/cs Consumables 1 Log in for price
FSL0-1118-1850 Biotage® SNAP KP-C18-HS 1850 g, 1/cs Consumables 1 Log in for price
FSN0-0909-0900 Biotage® SNAP KP-NH 900 g, 1/cs                Consumables 1 Log in for price
FSN0-0909-1800 Biotage® SNAP KP-NH 1800 g, 1/cs                Consumables 1 Log in for price
FSUL-0401-0950 Biotage® SNAP Ultra C18 950 g, 1/cs Consumables 1 Log in for price
FSUL-0401-1850 Biotage® SNAP Ultra C18 1850 g, 1/cs Consumables 1 Log in for price

ACCESSORIES

Part No. Description Product type Pack Size Price
412358 XL Fitting, Female Luer, Assembly - Isolera LS Accessories 1 Log in for price
412481 Sample Pump Tube, Fluran, Isolera LS Accessories 1 Log in for price
412537 Male Luer outlet fitting for SNAP 750g and 1500g cartridges Accessories 1 Log in for price
412891 Isolera LS, Sample pump inlet/outlet tubing kit Accessories 1 Log in for price
412896 Conductive PTFE tubing for Isolera LS funnel rack Accessories 8 Log in for price
DLV-500 DLV-500 Dry Load Vessel for Isolera LS, 1/cs Accessories 1 Log in for price
DLV-510 O-ring DLV500 Accessories 5 Log in for price
FNRK-032 Isolera LS funnel rack kit containing 1 portable cart, 2 funnel racks, leak detector, collection vessel tray and stabilizing rods Accessories 1 Log in for price

SPARE PARTS

Part No. Description Product type Pack Size Price
412303 Peristaltic Pump for Isolera LS Spare parts 1 Log in for price
412513 DLV Inlet Tube, Isolera LS Spare parts 1 Log in for price
412517 Cartridge Inlet Tube, Isolera LS Spare parts 1 Log in for price
412518 Cartridge Outlet Tube, Isolera LS Spare parts 1 Log in for price
412605 DLV to cartridge tube, Isolera LS Spare parts 1 Log in for price
412626 O-ring for DLV-500, Chemraz Spare parts 1 Log in for price
412630SP PUMP ISOLERA LS CPL Spare parts 1 Log in for price
413017 Isolera LS, Solvent inlet tubing kit (S1 to S4 incl filters) Spare parts 1 Log in for price
413019 Isolera LS, External tubing kit Spare parts 1 Log in for price
413081 Isolera LS-PM Kit Spare parts 1 Log in for price
413267 Cartridge inlet tube, Isolera LS Spare parts 1 Log in for price
415447SP Isolera LS, Solvent valve Spare parts 1 Log in for price
DLV-INTUBE DLV-500 inlet tube Spare parts 1 Log in for price