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Biotage ZIP® Sphere

High Performance, Low Pressure Flash Cartridge

Flash chromatography cartridges ZIP Sphere family
ZIP sphere 5g Flash Purification cartridge ZIP sphere 10g Flash Purification cartridges ZIP sphere 30g Flash Purification cartridge ZIP sphere 45g Flash Purification cartridge ZIP sphere 120g Flash Purification Cartridge Biotage ZIP® Sphere Silica cartridges, 10g Biotage ZIP® Sphere Silica cartridges, 10g

Biotage ZIP® Sphere delivers better purification and improved throughput than comparable flash cartridges. The silica surface area has been increased by 40%, meaning higher loading capacity, improved separations, and reduced purification time and solvent use.

Biotage ZIP® Sphere cartridges contain Biotage® KP-Sphere™, a proprietary spherical silica which is manufactured under a new process that delivers 40% more surface area (700 m2/g), no fines, and remarkably low back pressure. Typical flash cartridges use silica with a surface area of 500 m2/g and irregular particle sizes. The smallest particles or fines cause higher back pressure, lower flow rates and lower capacity.


  • High sample load compared to irregular silica particles
  • Time to purify is reduced
  • Less solvent required
  • Reduced purification costs 

Available in sizes from 5 g to 120 g