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Biotage®PS-Isocyanate is a 1% cross-linked poly(styreneco-divinylbenzene) which has pendent benzylisocyanate functionality. The resin can readily scavenge excess nucleophiles, which are often used to drive reactions to completion.
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I need to remove counter ion from peptidic molecules. Can I use PS-Trisamine to achieve this?
This will depend on the counter ion and peptide in question, and the state of protection/deprotection. A couple of scenarios are:
1) If the goal is to remove anions from a cationic peptide structure, then PS-Trisamine will only work in organic solvents.
2) If the solvents are aqueous or non-swelling, then MP-Trisamine may be useful. The better solution is Si-Carbonate or MP-Carbonate.
3) If the goal is remove cationic from a anionic peptide structure, then SCX-2 or MP-TsOH would be more helpful.Browse more questions and answers >