This technical note describes the use of derivatization techniques to separate aliphatic secondary amines from aliphatic tertiary amines in a mixture using the strong cation exchange sorbent, ISOLUTE® SCX-2.
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In this catalog product information is displayed with easy-to-follow application details and supporting documentation. Ordering information is found following each product listing.
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QuickStart Guide to SPE
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The first decision that needs to be made is what the final analysis will be for the analyte. This will have an impact on the sample and cartridge size, as well as the final elution solvent. Gas chromatography offers higher sensitivity than HPLC, while HPLC is better suited for ionisable species and very high molecular weights. If LC-MS is available, minimal sample clean-up may be required.
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Laboratory chemical Not for therapeutic or diagnostic use
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ISOLUTE S. C. X. – 2 9532 Laboratory chemical
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In medicinal chemistry, organic synthesis will generate by-products with similar chemistry to the product. Separating these impurities from the product often becomes a challenge that often only prep HPLC can achieve. In this poster, we discuss how using sample dry loading with a cation exchange scavenger media with flash chromatography improves product purity by removing many of the impurities.
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The ISOLUTE® family of cation exchange sorbents are used to extract organic cations (basic compounds capable of exhibiting a positive charge) from both aqueous and non-aqueous matrixes. Although extraction is by the same mechanism, each sorbent has properties that influence the way they are used.
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This technical note describes the use of derivatization techniques to separate aliphatic secondary amines from aliphatic tertiary amines in a mixture using the strong cation exchange sorbent, ISOLUTE® SCX-2.
Tags: Application Notes, Product Notes

In medicinal chemistry reactions are often carried out in solvents such as DMSO. Once the reaction is complete, it is usually necessary to separate the products of the reaction from reagents and by-products. This can be performed using strong cation exchange sorbents (e.g. ISOLUTE SCX-2 or ISOLUTE Flash SCX-2) to selectively isolate the basic compounds from the reaction mixture. (see Figure 1 for structure of ISOLUTE SCX-2 and ISOLUTE Flash SCX-2 sorbents)
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ISOLUTE® Si-Propylsulfonic acid (SCX-2) belongs to the class of strong acids. Similar to ISOLUTE Si-TsOH (SCX-3)1, it can be used to (a) scavenge amines and other bases such as anilines and borohydrides (b) as an acid catalyst in reactions or (c) as a replacement for aqueous or organic acids in quenching reactions. The advantage of using SCX-2 as a bound acid reagent is in that it eliminates work-up. The crude reaction mixture can be evaporated to dryness and the resulting free flowing solid can be purified directly by flash column chromatography.
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