Disulfide rich peptides (DRP) offer unique stability and plasticity when considering scaffolds for peptide-based therapeutics. With the recent FDA approval of Linaclotide, a 14 amino acid peptide with three disulfide bonds for the treatment of Irritable Bowel Syndrome, exemplifies the utility of this peptide class. While the linear synthesis of these peptides can be relatively straightforward, ensuring that the proper disulfide bond pattern is achieved reproducibly can be difficult but is absolutely critical for a successful discovery effort to proceed forward.
Learn simplified strategies that enable automated and regioselective formation of disulfide bonds in peptides with complex folding patterns.
Practicing peptide chemists, graduate students, postdoctoral scientists, laboratory managers, professors, peptide research program directors.
Ph. D. Elizabeth Denton, Biotage
30 October 2018
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