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Webinar Recording: Synthesizing Disulfide Rich Peptides

09 November 2018

This webinar recording demonstrates strategies to synthesize peptides containing one, two, or three disulfide bonds with regioselective control simplfied by the Initatior+ Alstra™ Branches™ software.

 

Disulfide rich peptides (DRP) offer unique stability and plasticity when considering scaffolds for peptide-based therapeutics. With the recent FDA approval of Linaclotide, a 14 amino acid peptide with three disulfide bonds for the treatment of Irritable Bowel Syndrome, exemplifies the utility of this peptide class. While the linear synthesis of these peptides can be relatively straightforward, ensuring that the proper disulfide bond pattern is achieved reproducibly can be difficult but is absolutely critical for a successful discovery effort to proceed forward.

Why Watch This?

Learn simplified strategies that enable automated and regioselective formation of disulfide bonds in peptides with complex folding patterns.

Who Should Watch?

Practicing peptide chemists, graduate students, postdoctoral scientists, laboratory managers, professors, peptide research program directors.

Watch the webinar on this link or in the player below

Disulfide Rich Peptides: Optimizing and automating syntheses with regioselective formation of disulfide bonds »

Presenter

Ph. D. Elizabeth Denton, Biotage

First Broadcasted

30 October 2018

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