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Press Release – Improved Sensitivity with the New Protein and Phospholipid Removal Columns

17 September 2015

Uppsala, Sweden, 17th September, 2015 – Biotage (STO: BIOT), a leading global supplier of solutions and technology for analytical, medicinal and peptide chemistry, is pleased to announce the extension of the ISOLUTE® PLD+ protein and phospholipid removal product line to include the versatile tabless 1 mL column format, for the clean-up of blood based matrix samples for analysis by LC-MS/MS. 

ISOLUTE® PLD+ 96-well plates and columns combine protein and phospholipid removal into a single product providing very effective and extremely simple sample clean-up for LC-MS/MS analysis. The new format is ideal for lower throughput applications, or for laboratories that have variable sample numbers to process.  Up to 96 columns can be processed using specially designed base plates, eliminating the problem of wasted unused wells. Utilizing the Biotage simple solvent crash / filter process ISOLUTE® PLD+ columns incorporate a phospholipid scavenging sorbent layer, which removes phospholipids from the sample during the filtration step.  ISOLUTE® PLD+ removes more than 99% of plasma proteins and phospholipids, the main causes of ion suppression, leading to cleaner extracts and increased sensitivity, signal-to-noise, for a broad range of analytes.

Once purified, samples can be analyzed directly, or evaporated and reconstituted in a solvent that matches your analytical method requirements. ISOLUTE® PLD+ products can be processed using compatible positive pressure manifolds (such as the Biotage® Pressure+ 96 or 48), vacuum manifolds (for example the Biotage® VacMaster™ range) and most automated liquid handling systems. 

“Requiring next to no method development, the new ISOLUTE® PLD+ 1ml tabless columns can be integrated quickly and easily into routine workflow, increasing productivity and reducing instrument downtime” says Dr Claire Desbrow, Product Manager, Analytical Chemistry, Biotage.

For further information go to the product page or call: in Europe +46 18 56 57 10, in North America toll free 1 800 446 4752, in Japan +81 3 5627 3123, other areas please call +46 18 56 57 10.



For further press information from Biotage please contact: James Churchill, Marketing Communications, Biotage GB Ltd. Distribution Way, Dyffryn Business Park, Ystrad Mynach, Hengoed, Wales  CF82 7TS  United Kingdom, Tel: +44 (0)1443 811 849  Mobile: +44(0)7875484778  Email:

About Biotage
Biotage offers solutions, knowledge and experience in the areas of analytical and medicinal chemistry. Customers include the world’s top pharmaceutical and biotechnology companies, as well as leading academic institutes. The company is headquartered in Uppsala, Sweden, with offices in China, Japan, the United Kingdom, the United States and a worldwide network of distributors. Biotage has 293 employees with sales of 490 MSEK in 2014. Biotage is listed on the NASDAQ OMX Nordic Stock Exchange. Website:


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