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Extraction of THC, Hydroxy-THC and Carboxy-THC from Oral Fluid Using ISOLUTE® SLE+

16 January 2017

This application note describes the extraction of THC, THCA and Carboxy-THC from oral fluid matrix collected using the NeoSal™ devices, prior to GC/MS analysis.


ISOLUTE SLE+ columnsISOLUTE® SLE+ supported liquid extraction plates and columns offer an efficient alternative to traditional liquid-liquid extraction (LLE) for bioanalytical sample preparation, providing high analyte recoveries, no emulsion formation, and significantly reduced sample preparation.

This application note describes an effective and efficient ISOLUTE SLE+ protocol optimized for 1 mL sample volumes. The simple sample preparation procedure delivers clean extracts and analyte recoveries greater than 70% with RSDs lower than 5% for all analytes.


  • THC
  • THC-OH

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ISOLUTE® SLE+ Supported Liquid Extraction