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Extraction of Cocaine From Oral Fluid Using ISOLUTE® SLE+ After Collection With NeoSal™ Collection Device

08 February 2017

This application note describes the extraction of cocaine and selected metabolites from oral fluid matrix following the collection with the NeoSal™ devices, prior to GC/MS analysis.



ISOLUTE® SLE+ Supported Liquid Extraction plates and columns offer an efficient alternative to traditional liquid-liquid extraction (LLE) for bioanalytical sample preparation, providing high analyte recoveries, no emulsion formation, and significantly reduced sample preparation. 

This application note describes an effective and efficient ISOLUTE SLE+ protocol optimized for 1 mL sample volumes. The simple sample preparation procedure delivers clean extracts and analyte recoveries greater than 76% with RSDs lower than 10% for all analytes.


  • Anhydroecgonine methyl ester (AEME)
  • Ecgonine (EME)
  • Norcocaine
  • Cocaine
  • Cocaethylene
  • Benzoylecgonine-D3 (BZE-D3)
  • Benzoylegonine (BZE)


Download the Application Note below »