The research group specializes in Polo-like kinases (PLK) – a family of serine/threonine enzymes playing a critical role in the regulation of mitosis – and the inhibition of these. In a series of studies they have described the stereoselective synthesis of (1R,2S)-2-(1H-indazol-6-yl)spiro[cyclopropane-1,3′-indolin]-2′-ones as PLK4 Inhibitors, and now report one of these as a novel clinical candidate for cancer therapy.
Microwave reactions were performed on a Biotage® Initiator+ microwave synthesizer, and subsequent purification of intermediates and final products on an Isolera™ One flash purification system with Biotage® SNAP KP-Sil flash cartridges.
Sampson PB, Liu Y, Forrest B, Cumming G, Li SW, Patel NK, Edwards L, Laufer R, Feher M, Ban F, Awrey DE, Mao G, Plotnikova O, Hodgson R, Beletskaya I, Mason JM, Luo X, Nadeem V, Wei X, Kiarash R, Madeira B, Huang P, Mak TW, Pan G, Pauls HW. 2015. The discovery of Polo-like kinase 4 inhibitors: identification of (1R,2S).2-(3-((E).4-(((cis).2,6-dimethylmorpholino)methyl)styryl). 1H.indazol-6-yl)-5'-methoxyspiro[cyclopropane-1,3'-indolin]-2'-one (CFI-400945) as a potent, orally active antitumor agent. J Med Chem. 2015 Jan 8;58(1):147-69
Extraction of Semi-Volatile Analytes from Wastewater - New Application Note
Determination of Diquat and Paraquat in Drinking Water - New Application Note
Extraction of THC and its Metabolites from Human Nails - New Application Note
New Method for Determination of Voriconazole in Plasma
Biotage Receives the SwedenBIO Award 2019