"We’re working on inhibition of kinase targets for various muscle cachexia, or muscle-wasting. There is a big push for muscle cachexia, for example people who sit in a hospital bed all day and begin to lose their muscle. These tests will hopefully identify a drug that will induce muscle growth and reverse atrophy.
[Using flash chromatography] is extremely important, you can’t do any medchem projects without strict-quality control. The risk of being misled is just too high. Using the Isolera plus the columns allows us to have super clean results on our high-resolution mass-spec and NMR spectra and, ultimately, confidence in our assay results.
For me it’s always the Isolera. I might use something else if I dry-load but liquid loading is generally sufficient and expedient, and that means the Isolera. I’ll use it in combo with the V-10 Touch because it’s efficient and fast to use them together. I can knock out 16 purifications with the Isolera and then dry them on the V-10 quicker than using a rotavap and round-bottom flasks without risk of solvent bumping. I use the entire Biotage suite when working in the lab. With the Isoleras we setup for reverse-phase, I tend to use the 13 x 100 racks such that fractions are eight milliliters. The V-10 Touch dries these in a 20 mL bottle under 10 minutes with minimal heating; it’s a great setup."
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