Biotage PhyPrep Automated Plasmid Purification Wins Market Acceptance

Plasmids are the common starting material for viral vectors, recombinant proteins, mRNA and DNA vaccines. With the rapid growth of interest in cell therapy, gene therapy and advanced therapeutics, the demand for pure DNA plasmids is exponential increasing. However, technological development in this field has lagged behind, and the highly manual plasmid preparation process has remained the same for the last 40 years.

In June 2021 Biotage launched PhyPrep, the first automatic plasmid purification system for Maxi, Mega and Giga scale plasmid DNA preparations, the scales primarily used in development phases prior to clinical and manufacturing scales. Since the introduction, Biotage PhyPrep has been evaluated, purchased and installed at many of the leading pharmaceutical, biotech and contract manufacturing companies across the globe. Applications have been in the fields of recombinant proteins, mRNA therapeutics and viral vectors. Leading academic institutions and governmental medical agencies have also evaluated and adopted Biotage PhyPrep, and multi system orders have been received as companies move from reliance on manual methods to adopt the new automated methodology.

‘The PhyPrep system fills a large demand in making DNA plasmid purification more efficient’ says Raffaella Bombarda, EVP Marketing at Biotage. ‘It is pleasing to see that the uptake of sales across geographies and industries illustrates that the technology has been accepted by leading experts in advanced therapeutics as a viable and more efficient alternative to older, manual techniques. Such as been the impact that customers have bought multiple systems to completely remove their reliance on manual methods and expensive outsourcing.’

Read more about the ground breaking Biotage PhyPrep Maxi Mega Giga here.