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Certificates English

Declaration of Conformtiy RapidTrace

Certificates Clinical English Environmental Food Forensic Product Notes

This application note describes a simple, effective protocol for the extraction of methylmalonic acid (MMA) from serum using EVOLUTE® EXPRESS AX solid phase extraction plates. Samples are prepared using the EVOLUTE EXPRESS load-wash-elute procedure. The method can be easily automated using the Biotage Extrahera. Details of the automated procedure and data comparing manual and automated method performance are included.

96-well plate Acidic Application Notes Biomarker Clinical English Extrahera LC-MS/MS MMA (Methylmalonic acid) Methylmalonic acid (MMA) Serum

This application note describes a simple, effective protocol for the extraction of methylmalonic acid (MMA) from serum using ISOLUTE® SAX strong anion exchange solid phase extraction plates, demonstrating high, reproducible analyte recoveries with low protein and phospholipid content in the extracts. Very clean extracts are possible due to the purely anion exchange retention mechanism available using this silica based sorbent. This minimizes the co-extraction of endogenous interferences through hydrophobic (or non-polar) retention. The method can be easily automated using the Biotage Extrahera. Details of the automated procedure and data comparing manual and automated method performance are included.

96-well plate Acidic Application Notes Biomarker Clinical English Extrahera LC-MS/MS MMA (Methylmalonic acid) Methylmalonic acid (MMA) Serum

This application note describes a simple, effective ISOLUTE® PLD+ protocol for the extraction of methylmalonic acid (MMA) from serum, demonstrating high, reproducible analyte recoveries with low protein and phospholipid content in the extracts. The method can be easily automated using the Biotage Extrahera. Details of the automated procedure and data comparing manual and automated method performance are included.

96-well plate Acidic Application Notes Biomarker Clinical English Extrahera LC-MS/MS MMA (Methylmalonic acid) Methylmalonic acid (MMA) Serum

This application note describes the extraction of methylmalonic acid from serum, prior to LC-MS/MS analysis. An effective and efficient ISOLUTE® SLE+ protocol optimized for the 200 μL capacity 96-well plate format is used. The simple sample preparation procedure delivers clean extracts and analyte recoveries greater than 80% with RSDs below 10%. The method can be easily automated using the Biotage Extrahera. Details of the automated procedure and data comparing manual and automated method performance are included.

96-well plate Acidic Application Notes Biomarker Clinical English Extrahera LC-MS/MS MMA (Methylmalonic acid) Methylmalonic acid (MMA) Serum

Biotage® Extrahera™ is a powerful, user friendly automation system for Supported Liquid Extraction (SLE) and Solid Phase Extraction (SPE) based methods, in plate or column formats.

Brochures

TurboVap LV Product Note

Product Notes

Product Note: ISOLUTE FILTER+ High Performance Filter Plates

96-well plate Clinical English Forensic Pharma Product Notes

English Manuals & User Guides

In this catalog product information is displayed with easy-to-follow application details and supporting documentation. Ordering information is found following each product listing.

Catalogs

German translation of the Biotage® Flash 75/150 Grounding Instructions (F-MFG-020-C).

German Manuals & User Guides

Norwegian translation of the Biotage® Flash 75/150 Grounding Instructions (F-MFG-020-C).

Manuals & User Guides Norwegian

Catecholamine metabolites vanillylmandelic acid (VMA), homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5 HIAA) are biomarkers for neuroblastoma and catecholamine-secreting tumors. This poster presents optimization of the method development process to maximize analyte sensitivity in the extraction and quantitation of these metabolites from plasma. Sample preparation protocols using solid phase extraction (EVOLUTE EXPRESS ABN and AX) and supported liquid extraction (ISOLUTE SLE+) are presented. MSACL NA 2018 Palm Springs, CA

5-hydroxyindoleacetic acid (5-HIAA) 96-well plate Acidic catecholamine metabolites Catecholamines Clinical English Forensic Homovanillic acid (HVA) LC-MS/MS Plasma Posters Vanillylmandelic acid (VMA)

This poster compares sample preparation options (solid phase extraction using EVOLUTE EXPRESS ABN, and supported liquid extraction using ISOLUTE SLE+) for the extraction of a panel of endogenous steroids from serum. MSACL NA 2018, Palm Springs, CA ASMS 2018, San Diego, CA

96-well plate Clinical English LC-MS/MS Posters Serum Steroid Hormones Steroid metabolite

This poster discusses the effect of various sample preparation protocols of the recovery of a range of different Drugs of abuse classes, extracted from oral fluid collected using the Quantisal collection device. MSACL NA 2018, Palm Springs CA ASMS 2018, San Diego, CA

Anaesthetic Anticonvulsant Benzodiazepines Cannabinoid Carbamates Clinical Column English Forensic LC-MS/MS Opioid Oral fluid Posters Saliva Stimulants Tricyclic Antidepressant z-drugs

This application note describes a solid phase extraction protocol for the extraction of three catecholamine metabolites (vanillylmandelic acid, homovanillic acid and 5-hydroxyindoleacetic acid) from plasma prior to LC-MS/MS detection. The method described in this application achieves high reproducible recoveries and excellent linearity (>0.99) in the range 10-200 ng/mL.

5-hydroxyindoleacetic acid (5-HIAA) 96-well plate Acidic catecholamine metabolites Application Notes Clinical English Homovanillic acid (HVA) LC-MS/MS Plasma Vanillylmandelic acid (VMA)

This application note describes the extraction of a panel of steroid hormones from human serum using ISOLUTE® SLE+ Supported Liquid Extraction plates prior to LC/MS-MS analysis. The simple sample preparation procedure delivers clean extracts and high, reproducible recoveries (>75%, RSD <10% ) for all analytes in human serum, with linearity >0.99 in the range 5–5000 pg/mL.

11-deoxycorticosterone 11-deoxycortisol 17-OH-Pregnenolone 17-alpha-hydroxyprogesterone 18-OH-Corticosterone 21-deoxycortisol 96-well plate Aldosterone Androstenedione Application Notes Clinical Corticosterone Cortisol Cortisone DHEA (dehydroepiandrosterone DHEAS Dehydroepiandrosterone (DHEA) Dihydrotestosterone (DHT) English Estradiol Estrogens Estrone LC-MS/MS Pregnenolone Progesterone Serum Steroid Hormones Steroid metabolite Testosterone