Part No: P218Issued year: 2020File size: 1.85mbFile type: pdf
Miniaturisation within various fields of analytical chemistry is not a
new phenomenon. Early phase small animal drug trials have largely
been the driver due to limited sample sizes available. However, this
trend is gaining popularity in forensic/clinical toxicology with
respect to alleviating patient discomfort, particularly in paediatrics.
Increased LC-MS/MS sensitivity has reignited this focus area. This
poster will evaluate a novel low-volume 96-well solid phase
extraction (SPE) format and potential application to forensic and
clinical toxicology. ASMS, 2020.
Part No: P194.V.2Issued year: 2020File size: 1.09mbFile type: pdf
Hair analysis is growing in popularity due to the non-invasive nature of the sample collection. Although not used as routinely as other matrices such as blood or urine it does have advantages in that the matrix can indicate prolonged drug exposure. NCFM 2020, Reykjavik, Iceland
Part No: P194Issued year: 2019File size: 1.08mbFile type: pdf
Sample preparation for hair analysis is often lengthy involving multiple manual labor steps from cutting, washing, homogenization/pulverization, digestion, sample extraction and analysis. This poster aims to demonstrate a streamlined sample
preparation workflow for hair analysis.
The workflow is evaluated using a suite of drugs of abuse, including THC and metabolites.
MSACL NA 2019
Part No: AN915Issued year: 2019File size: 1.53mbFile type: pdf
This application note describes the extraction of 25 illicit and prescribed drugs from hydrolyzed urine using ISOLUTE® HYDRO DME+ Dual Mode Extraction plates prior to UPLC-MS/MS analysis.
Because of the enhanced sample clean up delivered by ISOLUTE HYDRO DME+ products, analyte sensitivity is significantly increased compared to traditional dilute and shoot (D&S) techniques, resulting in reduced limits of quantitation (LOQ)
Part No: AN898Issued year: 2018File size: 1.91mbFile type: pdf
This application note describes a procedure for sample
pre-treatment and extraction of a panel of 49 drugs of
abuse from human hair, using Biotage® Lysera for matrix
micropulverization, prior to clean up using ISOLUTE® SLE
supported liquid extraction. The application note contains
procedures optimized for 400 μL capacity column format and
200 μL and 400 μL supported liquid extraction plate formats,
for higher throughput applications. The methodology delivers
clean extracts and analyte recoveries mostly greater than
80% with RSDs lower than 10% for all analytes and LLOQ from
Part No: P217Issued year: 2020File size: 1.3mbFile type: pdf
Dilute and shoot (D/S) is the most common form of sample preparation for the high throughput analysis of drugs of abuse (DoA)in urine. Although superior in extract cleanliness, solid phase extraction is sometimes deemed too complex, expensive and time consuming especially when matrix hydrolysis is required. This poster aims to demonstrate a simplified sample preparation workflow utilizing on-plate urine hydrolysis, organic solvent precipitation followed by flow through filtration and matrix component scavenging. ASMS, 2020.