Part No: AN111-HORIssued year: 2016File size: 2.03mbFile type: pdf
The compound 4-methylimidazole (4-MEI) is formed as a byproduct in some foods and beverages. Caramel coloring Type III and Type IV in beverages is one of the ingredients which may contain 4-MEI. Products that potentially contain 4-MEI include certain colas, beers, soy sauces, breads, coffee, ammoniated livestock feed and other products.
Part No: AN098-HORIssued year: 2014File size: 2.32mbFile type: pdf
Mycotoxin testing awareness has increased as countries involved in world trade of raw agriculture and processed consumer products rely on a safe global food supply. Several mycotoxins are naturally produced and monitored; however, aflatoxins, produced mainly by the Aspergillus species, are considered to be the most important mycotoxin group in the world’s food supply to monitor.
Part No: AN094-HORIssued year: 2014File size: 1.41mbFile type: pdf
When a sample preparation technique calls for removal of compounds using SPE, it is standard practice to determine what concentrations will produce an acceptable linear range for the assay. Traditional linear regression is often performed manually using pipettes to generate an external standard curve that unknown samples are measured against.
Part No: AN097-HORIssued year: 2014File size: 2.28mbFile type: pdf
Deoxynivalenol is a common mycotoxin found in wheat agriculture crops. Being the most popular agricultural cereal crop, wheat is also a dietary staple for about 35% of the global human population and animals. Safety of wheat food and agriculture products is a concern, with deoxynivalenol present in 90% of food and feed samples.
Part No: AN089-HORIssued year: 2014File size: 2.48mbFile type: pdf
Deoxynivalenol is a common mycotoxin found in agricultural grain crops and final consumer processed products. Most impacted are wheat, barley, and corn. Deoxynivalenol, also known as Vomitoxin, is produced by Fusarium fungi and has a unique dual-stage growth cycle of producing mold during warm daylight and toxin during cool nights. There is no known procedure or processing that will remove deoxynivalenol that is already present in grain.
Part No: AN096-HORIssued year: 2014File size: 2.89mbFile type: pdf
Mycotoxin testing in consumer food products has become increasingly important as global food trade increases, making it necessary to identify mycotoxins efficiently and accurately. Deoxynivalenol, also known as vomitoxin, is a mycotoxin commonly found in wheat feed crops. Because wheat is a highly-used raw agricultural export commodity in many counties for both animal feed and consumer food products, it is an important component in the diets of both humans and animals.
Part No: AN100-HORIssued year: 2015File size: 3.44mbFile type: pdf
Disinfection by-products (DBP) are an ever-present nuisance in the efforts to purify drinking water, wastewater and municipal waters from various sources. An emerging class of DBP compounds with health effects is nitrosamines1-3 which result from chloramination or chlorination if the water is nitrogen-rich.
Part No: AN085-HORIssued year: 2013File size: 2.07mbFile type: pdf
The data given in this Application Note illustrates the fact that the combination of the Biotage(R) Horizon SmartPrep Automated Extractor, DryVap Concentrator, and DryDisk Separation Membranes represent a complete solution to the preparation of samples for the extraction of semi-volatile organics by EPA Method 525.3.
Part No: AN107-HORIssued year: 2016File size: 1.59mbFile type: pdf
China has set ambitious goals for cleanup and monitoring of drinking water. Methods that are rugged and sensitive are required to support this effort. Chinese Environmental Agency method SL 392-2007 has been developed for this purpose and specifies a C18 cartridge for extraction and GC/MS for the detection step.
Part No: AN095-HORIssued year: 2014File size: 2.85mbFile type: pdf
The global demand for fish as a natural source of fresh animal protein, essential fats, minerals, and vitamins continues to rise with the human population. It is estimated that natural fish resources will not be sustainable, creating the need to increase the available supply of fish through aquaculture.
Part No: AN106-HORIssued year: 2016File size: 1.4mbFile type: pdf
Worldwide, there is great concern for the presence of semi-volatile organic compounds in surface water, groundwater, and drinking water, such as Aldrin, extremely toxic to fish and a persistent organic pollutant. China has increased concern about drinking water as sources of surface and groundwater have become polluted with microbiological, metal and organic contamination
Part No: AN082-HORIssued year: 2012File size: 0.85mbFile type: pdf
The focus of this Application Note is to illustrate some of the advances which have been made when performing EPA method 525.2 when using Solid Phase Extraction (SPE). It will make use of the Biotage(r) Horizon SmartPrep Automated Cartridge Extraction system set up to run in Bottle Rinse Mode with 6 mL SPE cartridges.
Part No: AN084-HORIssued year: 2012File size: 1mbFile type: pdf
Within EPA Method 549.2, the suggested rate to load a sample onto a solid phase cartridge is given as 3 to 6 mL/min.
This Application Note outlines the process used to extract diquat and paraquat from water samples using a faster loading rate than given by the EPA in method 549.2
Part No: AN093-HORIssued year: 2014File size: 1.58mbFile type: pdf
Routine research at the LVR-Hospital Viersen (Clinic for Psychiatry and Psychotherapy of the National Rhineland Association) includes screening of drugs in human urine. Successful treatment of pain disorders rely on sustainable and objective patient data. Routine Urine Drug Testing (UDT) is fast becoming a common method for obtaining regular results that can be used to effectively manage a patient’s pain therapy.
Part No: AN092-HORIssued year: 2014File size: 1.59mbFile type: pdf
The United States Food & Drug Administration (FDA) regulates the approval of color additives for their safe use in foods, cosmetics, pharmaceuticals/drugs, and medical devices. The Federal Food, Drug, and Cosmetic Act (FD&C Act) contains provisions for what color additives are required to be certified. These provisions are monitored by the FDA, and through the Code of Federal Regulations (CFR), the FDA releases information on new color additives and new uses for certified color additives.
Part No: AN073-HORIssued year: 2012File size: 0.79mbFile type: pdf
Solid Phase Extraction (SPE) cartridges have been used for many years, and are well established as a proven extraction,
clean-up, and fractionation technique for a wide variety of
sample matrices. As such, a diverse set of chemistries are
available to handle these various samples. For all of this
work, cartridges can be used manually, via a manifold-type
setup, or with an automated system, which would simply
automate the manual steps.
Part No: AN070-HORIssued year: 2012File size: 0.78mbFile type: pdf
Analytical methods which extract aqueous samples require
that the initial volume of the sample be determined, as it is necessary to calculate the concentration of the analytes in the sample. Typically, this is done by marking the sample
meniscus on the side of the sample bottle before the sample
Part No: AN090-HORIssued year: 2014File size: 1.49mbFile type: pdf
The US EPA has implemented an exposure research program aimed at conducting drinking water research on methods as part of the Microbiological and Chemical Exposure Assessment. This research is aimed at evaluating the chemical pollutants and their role and levels in which there is an unacceptable risk to either humans or wildlife, as well as evaluating the methodologies currently being used to determine levels of chemical pollutants
Part No: AN075-HORIssued year: 2016File size: 1.65mbFile type: pdf
The chemical 1,4-dioxane is primarily used as an industrial solvent or solvent stabilizer. Its carcinogenic classification by US EPA in Group B2 and by the state of California in Proposition 65 (safe harbor limit of 30 μg/day) along with its more recent detection in multiple groundwater supplies across the US have led to its placement on the UCMR 3 list to evaluate its occurrence in
drinking water supplies. This has increased demand for testing.