Part No: PPS466Issued year: 2017File size: 1.4mbFile type: pdf
Using the Biotage automated workflow, models have shown that the time taken to produce a target molecule can be reduced by up to eighty percent, allowing project delivery timescales to be reduced
Part No: PPS356Issued year: 2014File size: 1.19mbFile type: pdf
To save money on consumables, many chemists choose to reuse
silica flash cartridges. This is true but risks purification results because chromatographic separation performance will change from run to run which reduces purification quality, especially in normal phase systems.
Regardless of the cartridge brand used, repeated use of silica flash cartridges results in loss of compound resolution and therefore fraction purity.
Part No: TechTipIssued year: 2011File size: 0.07mbFile type: pdf
It’s important to replace these filters to ensure proper operation and protection of the internal solvent delivery valves. This filter not only traps particulates, but also protects the valves as particulates may get trapped within and could lead to improper solvent dispensing even when the extractors are at idle.
Part No: TN121Issued year: 2006File size: 0.07mbFile type: pdf
In medicinal chemistry reactions are often carried out in solvents such as DMSO. Once the reaction is complete, it is usually necessary to separate the products of the reaction from reagents and by-products. This can be performed using strong cation exchange sorbents (e.g. ISOLUTE SCX-2 or ISOLUTE Flash SCX-2) to selectively isolate the basic compounds from the reaction mixture. (see Figure 1 for structure of ISOLUTE SCX-2 and ISOLUTE Flash SCX-2 sorbents)
Part No: TN135.06Issued year: 2006File size: 0.09mbFile type: pdf
One of the most common work-up techniques in medicinal chemistry is liquid-liquid extraction (LLE) using a
separating funnel. The technique is used for removal of water soluble impurities, solvent exchange, water
removal or work-up of aqueous reaction mixtures.
Part No: TN135Issued year: 2006File size: 0.1mbFile type: pdf
One of the most common work-up techniques in medicinal chemistry is liquid-liquid extraction (LLE). The technique is used for removal of water soluble impurities, solvent exchange, water removal or work-up of aqueous reaction mixtures.
Part No: PPS352Issued year: 2017File size: 2.55mbFile type: pdf
Biotage offers a range of products for reaction mixture work-up and organic sample preparation. The solutions include a range of techniques and also address throughput requirements from filtration, catch & release, and scavenging cartridges in organic synthesis workflows.