Part No: P217Issued year: 2020File size: 1.3mbFile type: pdf
Dilute and shoot (D/S) is the most common form of sample preparation for the high throughput analysis of drugs of abuse (DoA)in urine. Although superior in extract cleanliness, solid phase extraction is sometimes deemed too complex, expensive and time consuming especially when matrix hydrolysis is required. This poster aims to demonstrate a simplified sample preparation workflow utilizing on-plate urine hydrolysis, organic solvent precipitation followed by flow through filtration and matrix component scavenging. ASMS, 2020.
Part No: P198.V.3Issued year: 2020File size: 0.59mbFile type: pdf
Hair analysis is growing in popularity due to the non-invasive nature
of the sample collection. Although not used as routinely as other
matrices such as blood or urine it does have advantages in that the
matrix can indicate prolonged drug exposure. This can provide
valuable information with respect to therapeutic drug regimens or
in abused drug abstinence cases. MSACL, 2020.
Part No: AN894Issued year: 2018File size: 1.17mbFile type: pdf
This application note describes the simultaneous extraction of aldosterone at low (< 25pg/mL) concentration and angiotensin I and II from plasma, with the potential to improve throughput and reduce time and costs in PRA determination.
Part No: P155Issued year: 2017File size: 0.61mbFile type: pdf
This poster discusses the impact of optimization of various parts of the method development process to maximize assay performance while delivering a combined assay for the analysis of urinary catecholamines and metanephrines. The extraction method using EVOLUTE EXPRESS WCX 96-well plates is successfully automated using the Biotage® Extrahera™ Automated Sample Preparation Platform.
MSACL 2017, Palm Springs
ASMS 2017, Indianapolis
Part No: AN755Issued year: 2012File size: 1.03mbFile type: pdf
Ethyl glucuronide (EtG) and ethyl sulphate (EtS) are specific metabolites formed within the body after the ingestion of alcohol. In forensic toxicology, when tested together they provide more specific evidence of alcohol intake. This application note demonstrates the simultaneous extraction of both EtG and EtS in the same assay and represents further optimization of AN718 which showed single EtG extraction without EtS. Recoveries for EtG range from 90-105% and 80-103% for EtS across two formats of EVOLUTE AX columns with RSDs <10%. The LOQ is 10 ng/mL for EtG and 2 ng/mL for EtS across both EVOLUTE AX formats.
EVOLUTE AX, EVOLUTE, EtS, EtG, Ethyl Glucuronide, Ethyl Sulfate, SPE, Anion Excange, Urine, OASIS, Waters, Polymeric, Polmers,
Part No: UI449Issued year: 2020File size: 0.16mbFile type: pdf
The following document will assist you in the preparation of your facility for a successful installation of Biotage® Flash System. This document must be read in connection with the full engineering specification site document.
Part No: UI412Issued year: 2019File size: 0.11mbFile type: pdf
The following document will assist you in the preparation of your laboratory for a successful installation of DryVap®. Please read and sign where indicated at the end of this document. Your signature validates that you have understood our requirements.
Part No: P203Issued year: 2019File size: 0.86mbFile type: pdf
Breast feeding is beneficial in meeting the nutritional and immunological needs of infants. Using illegal drugs while breast feeding can have severe consequences for both infant and mother. We have developed a new extraction protocol for 12 common drugs of abuse (DOA) to be detected in breast milk, utilizing EVOLUTE EXPRESS CX and Biotage(R) Extrahera for sample processing.
Part No: AN098Issued year: 2014File size: 0.81mbFile type: pdf
To demonstrate the cost savings by employing small μmol scale automated solid phase peptide synthesis through robot liquid handling of reagents with accurate dispensing of small volumes, a 10-mer antimicrobial peptide was synthesized.