Part No: AN098Issued year: 2014File size: 0.81mbFile type: pdf
To demonstrate the cost savings by employing small μmol scale automated solid phase peptide synthesis through robot liquid handling of reagents with accurate dispensing of small volumes, a 10-mer antimicrobial peptide was synthesized.
Part No: AN073-HORIssued year: 2012File size: 0.79mbFile type: pdf
Solid Phase Extraction (SPE) cartridges have been used for many years, and are well established as a proven extraction,
clean-up, and fractionation technique for a wide variety of
sample matrices. As such, a diverse set of chemistries are
available to handle these various samples. For all of this
work, cartridges can be used manually, via a manifold-type
setup, or with an automated system, which would simply
automate the manual steps.
Part No: AN070-HORIssued year: 2012File size: 0.78mbFile type: pdf
Analytical methods which extract aqueous samples require
that the initial volume of the sample be determined, as it is necessary to calculate the concentration of the analytes in the sample. Typically, this is done by marking the sample
meniscus on the side of the sample bottle before the sample
Part No: Issued year: 2008File size: 0.13mbFile type: pdf
The adapter kit contains a pre-assembled stand, spacer and
connecting tubing; everything required to allow the use of
SNAP 340g cartridges on flash purification systems that utilize
Luer tubing connections such as, Isco Companion and Analogix
Part No: install_snap_25.zipIssued year: 2012File size: 0mbFile type: zip
7742_install_snap_25.zip. SPX 25 g SNAP cartridge installation.
The system already has the SNAP 10 g, 50 g, 100 g and 340 g cartridges installed
(only the SNAP 25 g needs to be installed)
Part No: install_snap_full.zipIssued year: 2012File size: 0mbFile type: zip
install_snap_full.zip. SNAP Software Update for Biotage® SP Systems. SPX FULL SNAP cartridge installation instructions.
The systems that does not have any SNAP cartridges installed
(the SNAP 10 g, 25 g, 50 g, 100 g and 340 g will be installed)
Part No: TN-SNAP XL-0211Issued year: 2011File size: 1.22mbFile type: pdf
The SNAP XL cartridges address a growing need for optimized gram- to ~100+ g-scale purification, increasing efficiency and reducing costs. These cartridges extend the
SNAP product ranges, providing chemists with more scalable tools for their synthesis and purification needs. There are 3 members in this family of cartridge solutions, KP-Sil for normal phase, C18 for reverse phase and KPNH for more difficult normal phase systems, such as amines. SNAP XL cartridges will allow you to save hours, even days of purification run-time.
Part No: BIOMARK140Issued year: 2020File size: 0.78mbFile type: pdf
Here at Biotage, we want to keep your Extrahera updated with the most efficient, user-friendly and easy to program software. So, every now and then, we issue software updates to stamp out any pesky software bugs or we introduce minor cosmetic changes.
This time we’re introducing features based on your feedback and it’s at no cost to you. No matter your current SW version, we can help you upgrade to 2.0.0.
Part No: AN121-HORIssued year: 2017File size: 1.67mbFile type: pdf
Environmental methods for water analysis often specify sampling 1 L of water to provide the sensitivity needed for determination of contaminants at low concentrations for health monitoring. In the past decade sensitivity of the analytical technique (GC/MS) has improved and with split/splitless introduction and large volume injection options a wide range of concentrations can be effectively measured.
Part No: AN090-HORIssued year: 2014File size: 1.49mbFile type: pdf
The US EPA has implemented an exposure research program aimed at conducting drinking water research on methods as part of the Microbiological and Chemical Exposure Assessment. This research is aimed at evaluating the chemical pollutants and their role and levels in which there is an unacceptable risk to either humans or wildlife, as well as evaluating the methodologies currently being used to determine levels of chemical pollutants
Part No: TN114Issued year: 2006File size: 0.12mbFile type: pdf
New approaches to the quantitation of drugs and metabolites in biological fluids have increased the need for high throughput methodologies to avoid the traditional laboratory bottleneck of sample preparation. Solid phase extraction in a 96-well plate format such as ISOLUTE-96 Fixed Well Plates or ISOLUTE Array 96-well Plates is a solution to this problem.
Part No: Issued year: 2013File size: 2.08mbFile type: pdf
Amide-linked homopolymers of sialic acid offer the advantages of stable secondary structure and increased bioavailability making them useful constructs for pharmaceutical design and drug delivery. Defining the structural characteristics that give rise to secondary structure in aqueous solution is challenging in homopolymeric material due to spectral overlap in NMR spectra. Having previously developed computational tools for heteroologomers with resolved spectra, we now report that application of these methods in combination with circular dichroism, NH/ND NMR exchange rates and nOe data has enabled the structural determination of a neutral, d-amide-linked homopolymer of a sialic acid analogue called Neu2en.
Keywords: sialic acid; Neu2en; NMR; circular dichroism; helical peptide; water-soluble scaffold; blood serum; proteolysis; 1,3-dipolar cycloaddition chemistry; click chemistry; Initiator+ SP Wave
Jonel P. Saludes, Travis Q. Gregar, I. Abrrey Monreal, Brandan M. Cook, Lieza M. Danan-Leon, Jacquelyn Gervay-Hague
Part No: Issued year: 2007File size: 0.22mbFile type: pdf
Biotage has created a new Resin-based Chemistry Kit that contains a variety of resins
designed to enable a choice of key resin-assisted chemistries with optimized protocols
(Figure 1). Reductive amination, coupling (C-C or C-O bond formation), amide bond
formation and oxidation are widely used traditional chemical transformations you’ll be able
to perform with this new kit.
Part No: TN-0021.0207Issued year: 2007File size: 0.34mbFile type: pdf
Resins are usually described as one of 2 main types, Gel (PS) or macroporous (MP).
The gel resins have a low cross-linking and need to swell to allow access to their
functional groups. Therefore, they are very effective in transformations requiring
swelling organic aprotic solvents such as DCM, THF, Dioxane etc. Conversely, MP
resins are more highly cross-linked with more of a permanent open pore structure,
so they do not require swelling in such solvents for effective performance. As a
result, MP resins are compatible with a wider range of solvents than PS resins and
perform better in solvents such as water, MeOH and MeCN. Resins are generally
stable and can be stored indefinitely under cool dry conditions. For longer term
storage standard refrigeration (4 °C) is recommended.
Biotage offers the widest range of solvent evaporation systems available. This guide presents the most suitable evaporation system for your research requirements, and answers common questions regarding service, maintenance and applications.
Keywords: turbovap, turbo vap, v10, v-10, spedry, spe dry, evaporation, concentrat
Part No: AN048-HORIssued year: 2009File size: 0.64mbFile type: pdf
The analysis of pesticides for environmental extracts typically requires a solvent exchange from dichloromethane (DCM) to an ECD compatible solvent such as nhexane. The prescribed method of solvent exchange and concentration is given in EPA Method 3510 and uses a Kudera-Danish(KD) apparatus to achieve the results.