Part No: AN127Issued year: 2019File size: 0.9mbFile type: pdf
Wetting and equilibration of C18 columns for flash chromatography
are best performed at the highest possible pressures/
flowrates in order to remove the air trapped inside the porous
material. That will make more C18-sites activated and accessible
during the chromatography run.
Part No: AN075-HORIssued year: 2016File size: 1.65mbFile type: pdf
The chemical 1,4-dioxane is primarily used as an industrial solvent or solvent stabilizer. Its carcinogenic classification by US EPA in Group B2 and by the state of California in Proposition 65 (safe harbor limit of 30 μg/day) along with its more recent detection in multiple groundwater supplies across the US have led to its placement on the UCMR 3 list to evaluate its occurrence in
drinking water supplies. This has increased demand for testing.
Part No: AN074-HORIssued year: 2016File size: 1.25mbFile type: pdf
The initial use of many chlorinated pesticides, herbicides, and organohalides were to aid humanity. DDT was created to control mosquito populations which significantly limited the number of malaria and typhus cases in World War II; while the use of Atrazine has increased the production of corn and sugar cane farms and helped to supply the world
with the food it so drastically needs.
Part No: AN083-HORIssued year: 2012File size: 1mbFile type: pdf
This Application Note outlines the process used to extract diquat and paraquat from water samples using the Biotage Horizon SmartPrep Automated Solid Phase Cartridge Extractor, according to EPA method 549.2.
Part No: AN113-HORIssued year: 2016File size: 1.48mbFile type: pdf
Perfluorinated chemicals (PFCs), also known as PFAAs, can be found in commercial and industrial uses such as firefighting foams, package material coatings, nonstick cookware, waterproofing and stain proof fabrics. PFCs are all manmade and have unique properties such as repelling water, oil and heat. They are very difficult to break down and persist in the environment.
Part No: Issued year: 2010File size: 1.9mbFile type: pdf
User Report: V-10, Sumitomo Dainippon Pharma. Sumitomo Dainippon Pharma is recognized worldwide for its highly creative drug discovery program for treating neuropsychiatric disorders, and in specialized areas with high unmet medical needs. Its Genomic Science Laboratories installed the V-10 evaporation system in 2008, which has been used extensively for drying in-house compounds. We asked two researchers at that facility, Mr. Masahiko Ikeda and Mr. Fumitaka Nishino, about their use of the V-10 in their daily work.
Part No: Issued year: 2005File size: 0.57mbFile type: pdf
Use of the unique opportunities of an academic environment for the synthesis of high-quality libraries of diverse chemical structures to discover small molecules with
architecturally novel scaffolds and a wide range of physicochemical properties and to develop innovative new methodologies for Diversity-Oriented Organic Synthesis
Part No: PPS537.V.1Issued year: 2018File size: 0.68mbFile type: pdf
One of the recent introductions is a system to extract a full range of acid/base neutral compounds from various types of water samples using a One-Pass system. In this case, rather than extract water at pH 2, adjust the pH of the water to 12 and re-extract, the water is passed once through a multi-media SPE disk and then a carbon cartridge before being delivered to waste. The elegance of this approach is the elimination of the basification step, which requires additional labor adjusting the pH and time passing the sample through the disk a second time after the first elution of acids and neutrals. The additional benefit of omitting the basification step eliminates the formation of insoluble metal hydroxides that can restrict the flow of sample through the disk or add significant time if a liquid-liquid extraction is used.
Part No: F0211609_01Issued year: 2011File size: 0.52mbFile type: pdf
Dioxins are persistent organic pollutants (POPs) that are of concern around the world. They need to be efficiently extracted and then are usually measured with HRGC/HRMS using methods such as US EPA 1613 or ISO 18073:2004 for guidance. The SPE-DEX 4790 using solid phase extraction disks is a well-established technology that can be used for this application.
Part No: TN115Issued year: 2006File size: 0.08mbFile type: pdf
This Chemistry Data Sheet describes the use of ISOLUTE® HM-N as a support material for pre-absorption of a
reaction mixture prior to flash chromatography. This approach is used as a solution to loading reaction
mixtures that are only soluble in polar solvents onto an ISOLUTE Flash SI II or Flash NH2 column.
Part No: TN118Issued year: 2006File size: 0.07mbFile type: pdf
ISOLUTE HM-N is a modified form of diatomaceous earth that can efficiently absorb aqueous samples. ISOLUTE HM_N is chemically inert and stable in the pH range 1-13. These characteristics make it a versabile material that plays an important role in many sample preparation applications.
Part No: Issued year: 2006File size: 0.83mbFile type: pdf
• Novo Nordisk A/S & radiochemistry at Novo Nordisk A/S
• Introduction to radiochemistry in general
• Radiochemistry & microwaves
• Selected case stories from the labs at Novo Nordisk A/S
• Applications of radiolabelled compounds
• Summary and acknowledgements