US EPA Method 1664 for Hexane Extractable Material (HEM) or Oil and Grease has allowed use of solid phase extraction (SPE) instead of liquid-liquid extraction (LLE) with hexane since 2007 and this has been widely adopted in the US. SPE is an equivalent extraction technique to LLE and produces the same n-hexane extract. The extract, similar to LLE, may contain residual water that must be treated properly and removed from the n-hexane extract.

Environmental Posters

This application note demonstrates that the Biotage(R) Horizon 4790 using Atlantic C18 disks can effectively extract hormone compounds from 1-L water samples in approx 40 mins.

11-ketotestosterone 17-alpha-estradiol 17-alpha-ethynylestradiol 17-beta-estradiol 4790 Androgens Androsterone Application Notes Diethylstilbestrol Dihydrotestosterone (DHT) Disk Endocrine disrupter English Environmental Epitestosterone Estradiol Estriol Estrogens Estrone GC-MS Hormones Mestranol Norethindrone Progesterone Steroid Hormones Steroid metabolite Surface water Testosterone Water

Analysis of the perfluorinated alkyl acids listed in EPA Method 537 along with fluorotelomeric alcohols and perfluorinated sulfonates were extracted using SPE (using ISOLUTE 101 500 mg/ 6 mL SDVB SPE columns) and analyzed on the LCMS 8045. Minimum Detection Limits(MDL) ranged from 0.69 to 3.25 ppt. Extraction recoveries were greater than 80% for all compounds, with surrogate recoveries within 10% of the true value.

Application Notes Column Drinking water English Environmental LC-MS/MS Polyfluorinated acids

This application note demonstrates the use of automated solid phase extraction for a variety of pharmaceutical compounds in drinking water, wastewater and surface water. The criteria specified in US EPA Method 1694 was met, even at very low concentrations. For lower concentrations a larger sample of water may be processed.

4790 Acetaminophen Albuterol Albuterol Application Notes Atenolol Caffeine Carbamazepine Cotinine DEET Dehydronifedipine Diclofenac Diltiazem Diphenhydramine hydrochloride Disk Drinking water English Environmental Gemfibrozil Ground water Ibuprofen LC-MS TOF Lamotrigine Metoprolol Naproxen Pharmaceuticals Sulfadimethoxine Sulfamethoxazole Triclocarban Trimethoprim Waste water

This application note describes the use of EVOLUTE® EXPRESS ABN on-line cartridges in a fully automated on-line SPE-LC-MS/MS method for extraction and quantification of 13 commonly prescribed pharmaceuticals (with a range of characteristics) in water.

Application Notes Atenolol Atorvastatin Azithomycin Carbamazepine Ciprofloxacin Clarithromycin Diclofenac English Environmental Erythromycin Fluoxetine On-line SPE On-line SPE-LC-MS/MS Pharmaceuticals Prednisolone Ranitidine Sertraline Tolytriazole Water

The method described in this application note achieves high recoveries of THC and an extended suite of common metabolites in oral fluid from Quantisal (Immunalysis) oral fluid collection devices. This application note describes effective and efficient ISOLUTE SLE+ protocols optimized for sample loading volumes of either 300 μL or 800 μL. The simple sample preparation procedure delivers clean extracts and analyte recoveries greater than 64% with RSDs of <10% for all analytes.

11-hydroxy- Δ9-tetrahydrocannabinol (THC-OH) 11-nor- Δ9-carboxy tetrahydrocannabinol (THC-COOH) 11-nor-9-carboxy- Δ9-tetrahydrocannabivarin (THC-V-COOH) 11-nor-9-carboxy- Δ9tetrahydrocannabinol glucuronide (THC-COOH-g 11-nor-9-carboxy-Δ9-THC glucuronide Application Notes Cannabidiol Cannabigerol Column Drugs of Abuse English Forensic LC-MS/MS Oral fluid Saliva THC THC metabolites THC-COOH Δ9-tetrahydrocannabinol (THC) Δ9-tetrahydrocannabivarin (THCV)

Urine samples are neutralized using 0.5 M ammonium acetate and loaded onto weak cation exchange (WCX) Evolute Express plates (Biotage), preconditioned with methanol and water. Samples are washed with 20 mM ammonium acetate and water before elution in 0.5 % formic acid. Department of Clinical Chemistry and Immunology, Heart of England NHS Foundation Trust, Birmingham, UK

Posters

Pesticides have gone far in increasing food supply, important in a world expecting to have 9.8 billion people by 2050. However, the mechanisms that make pesticides effective in eliminating pests can also cause harm to humans and animals. News stories continue to point to contamination through spills and exposure through the respiratory system.

5000 Application Notes Disk EPA 608.3 Analytes English Environmental GC-MS US EPA Method 608.3 Waste water

In this catalog product information is displayed with easy-to-follow application details and supporting documentation. Ordering information is found following each product listing.

Catalogs

Annual Maintenance Contract - India

Product Notes

A GC-MSMS method of simultaneously measuring legacy/emerging POPs PCBs, OCPs and PBDEs) in serum was developed and applied to this study of exposure of mothers to harmful environmental contaminants.

BHC Clinical DDE DDT English Environmental GC-MS HCB Organochlorine pesticides (OCP) Organochlorines Oxychlordane PBDE PBDEs PCB PCBs Persistant organic pollutants (POP) Posters RapidTrace Serum Trans-nonachlor

Polychlorinated Biphenyls (PCB) are a worldwide contamination problem. They are extremely stable and as such, very long lived in the environment. The end result is that PCBs tend to bioaccumulate throughout the food chain and a great deal of research and regulations have been dedicated to their study.

4790 Application Notes English Environmental GC-MS PCB PCBs US EPA Method 8082 Water

Argoresin MP-Isocyanate is a macroporous polystyrene-bound scavenger, for nucleophiles such as amines and alkoxides. Resin bound scavengers are added after a reaction is complete in order to quench and react selectively with excess reactants and/or reaction byproducts. The resulting resin-bound reactants are removed by simple filtration.

Product Notes

Argoresin MP-TMT is a macroporous polystyrene-bound trimercaptotriazine, a resin-bound equivalent of 2,4,6- trimercaptotriazine (TMT). The resin is designed to scavenge residual palladium from products derived from palladium catalyzed reactions.1 Despite the widespread use of palladium-mediated reactions, removal of residual palladium during workup and product isolation remains a major problem. Reducing the palladium content to the low parts per million (ppm) levels, as is required for active pharmaceutical ingredients, is particularly challenging.

Product Notes

Argoresin MP-Trisamine is a macroporous polystyrene-bound scavenger, for electrophiles such as acid chlorides, sulfonyl chlorides and isocyanates. Resin bound scavengers are added after a reaction is complete in order to quench and react selectively with excess reactants and/or reaction byproducts.

Product Notes