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Carbon Cartridge Selector
Traditionally decolorization was achieved by adding activated carbon powder to a solution and refluxing for several hours or even over several days. After refluxing, the hot solution is passed through a celite filter to remove the activated carbon powder from the product. An obvious drawback to this traditional decolorizing approach is the inefficiency of the batch process. Contact efficiency between the colored impurities and the activated carbon particles can be thermodynamically low. Biotage prepacked carbon cartridges offer numerous advantages and benefits.
Use the cartridge selector below to quickly identify compatible cartridges for your purification platform and / or view available cartridges by size. (Carbon is approximately 60% of the density of silica, so will weigh a little less in a similar sized cartridge). Development and process development scale cartridges intended for use on Biotage® Selekt or our larger scale development platform Biotage® Isolera LS connect to the system via universal Luer-lock style connectors. Cartridges for our larger process development and scale up systems Biotage® Flash 75 / Flash 150 or Flash 400 systems require a compression module which is provided with the system, or available as a spare part (links open in a new window).
For over 20 years Biotage has been at the forefront of enabling purification technologies. Our Carbon products add a significantly capability relating to purification by adsorptive methods. Classically, carbon has been used to decolourize samples and purify products from organic reactions, and the application of this media in a fixed bed, greatly enhances those processes.
Moving from lab scale to large scale comes with a number of additional considerations. Biotage® Isolera LS, Flash 75, 150 and 400 systems are extremely tough, economically viable scale-up purification systems that have been developed for this purpose. With the Biotage approach, scaling up a number of different purification techniques is possible. Any method developed using a Biotage lab scale cartridge can be transferred to a larger cartridge using scale-up factors. Once the development cartridge is determined and breakthrough conditions identified, the lab scale method can be replayed, providing peak elution profiles for the expected scale up run which are suitable for further optimization if needed. A well-packed cartridge has hundreds or thousands of theoretical plates (equilibrium stages) that are available to interact with the colored product. As a sample moves down the cartridge, it has the opportunity to interact with each plate thus increasing the equilibrium distribution of colored impurities in the stationary phase (activated carbon) and removes the impurities from the liquid phase much more efficiently and rapidly. Each of the larger flash systems may be configured with either ‘M’ or ‘L’ cartridge capability to further increase its flexibility and range.
Key supplier to industry for over 20 years, used in numerous patents and cGMP processes.
Purification from grams in development through to multi kilogram quantities of product for pre-clinical and commercial production campaigns.
Stationary phase silica is clean, inert and deployed to support the most demanding of purification goals.
With lot control, an extensive QA / QC documentation package including Safety Data sheets, ISO 9001 / 14001 registration certification, BSE / TSE statement, shelf-life statements, retest guidance, storage recomendations and more, Biotage silicas are deisnged for industry and professional scale up campaigns.
