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What's the best way to scale-up flash chromatography?
Small Molecules and Synthetic Therapeutics
This post discusses a simple, direct route for flash chromatography scale-up.
When should I use C18 rather than silica for flash chromatography?
Small Molecules and Synthetic Therapeutics
This post discusses when reversed-phase flash should be used instead of normal-phase.
How to improve synthesis workflow by over 90%
Small Molecules and Synthetic Therapeutics
This post shows the time savings achievable by using automated Biotage synthesis, evaporation, and purification equipment.
What should I use instead of DCM/MeOH flash chromatography for purification?
Small Molecules and Synthetic Therapeutics
This post discusses the practical benefits of reversed-phase over DCM/MeOH flash chromatography.
How do I purify ionizable organic amine compounds using flash column chromatography?
Small Molecules and Synthetic Therapeutics
This post discusses the challenges of purifying organic amines and some suggested alternative chromatography techniques.
Purifying ionic compounds by flash column chromatography
Small Molecules and Synthetic Therapeutics
Purifying ionic compounds by flash column chromatography.
How does solvent choice impact reversed-phase flash chromatography separations?
Small Molecules and Synthetic Therapeutics
This post discusses the value that adding/switching solvents can bring to challenging separations.
Which sorbents work best for dry loading flash column chromatography samples?
Small Molecules and Synthetic Therapeutics
Which sorbents work best for dry loading flash column chromatography samples?
Determining solvent strength in flash column chromatography
Small Molecules and Synthetic Therapeutics
Determining solvent strength in flash column chromatography is important as it impacts separation effectiveness and fraction purity.
What is the Chemistry Behind Reversed-Phase Flash Chromatography?
Small Molecules and Synthetic Therapeutics
This post describes the mechanisms behind reversed-phase flash chromatography and where it is most beneficial.
