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Small Molecules and Synthetic Therapeutics

Head-to-tail macrocycles remain difficult to synthesize on resin. Here is how C-terminal amino acid affects cyclization efficiency.

Small Molecules and Synthetic Therapeutics

This post highlights the time and solvent savings attainable with shorter linear gradients when maintaining gradient slope.

Small Molecules and Synthetic Therapeutics

Head-to-tail macrocycles remain difficult to synthesize on resin. Here is how the length and size of your pepetide can affect purity and ...

Small Molecules and Synthetic Therapeutics

This post highlights the time savings achievable using a step gradient in reversed phase flash chromatography.

Small Molecules and Synthetic Therapeutics

This post discusses how Biotage(R) Sfar C18 can be used to remove color from a reaction product.

Small Molecules and Synthetic Therapeutics

This post discusses the pros and cons of adding acid to a flash purification method.

Small Molecules and Synthetic Therapeutics

This post discusses the benefits of UV baseline correction with flash chromatography.

Small Molecules and Synthetic Therapeutics

Head-to-tail macrocycles remain difficult to synthesize on resin. Here is how resin loading can affect purity and challenges associated ...

Small Molecules and Synthetic Therapeutics

This post examines the true reason silica particles are often found if flash chromatography fractions.

Small Molecules and Synthetic Therapeutics

This post discusses the benefits of using UV transparent solvents for flash chromatography to improve compound detectability.