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Does mass detection make-up solvent choice matter?
Small Molecules and Synthetic Therapeutics
Does mass detection make-up solvent choice matter?
How do I convert my HPLC method to flash chromatography?
Small Molecules and Synthetic Therapeutics
This post discusses the best options for creating and transferring HPLC-based methods to flash chromatography.
Acetone – a lower cost alternative to EtOAc in normal-phase flash column chromatography
Small Molecules and Synthetic Therapeutics
This post discusses the benefits of acetone over ethyl acetate in normal-phase flash chromatography.
Using pH to optimize reversed-phase flash chromatography separations
Small Molecules and Synthetic Therapeutics
Using pH to optimize reversed-phase flash chromatography separations.
In-line mass detection to find the undetectable in flash column chromatography
Small Molecules and Synthetic Therapeutics
This post describes the benefits of in-line mass detection to find the undetectable compounds when using flash chromatography.
Using adducts and fragments to identify compounds in mass-directed flash chromatography
Small Molecules and Synthetic Therapeutics
This post discusses how to use adducts and fragments to identify compounds in mass-directed flash chromatography.
What impact do buffers have on APCI mass detection?
Small Molecules and Synthetic Therapeutics
This post describes the impact buffers and acids have on APCI mass detection.
Packing a column is part science and part art...and Biotage has both
Small Molecules and Synthetic Therapeutics
The clip shows the long history in Biotage column chromatography.
Which dry load sorbent should I use for flash column chromatography?
Small Molecules and Synthetic Therapeutics
When dry loading with flash chromatography, the sorbent choice can impact compound purification effectiveness.
The three reasons you should be using step gradients for flash column chromatography
Small Molecules and Synthetic Therapeutics
Step gradient flash chromatography improves loading capacity, while reducing solvent use and overall purification time.
