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Small Molecules and Synthetic Therapeutics

SPE is emerging as a strategy for peptide library clean up in parallel.

Small Molecules and Synthetic Therapeutics

ELSD is useful for finding molecules that have no chromophore during flash purification. Here we show how signal intensity can vary between ...

Small Molecules and Synthetic Therapeutics

This post describes how ELSD make-up solvent choice can impact detected peak sensitivity.

Small Molecules and Synthetic Therapeutics

This post highlights the benefits achievable when using both UV and ELS detection.

Small Molecules and Synthetic Therapeutics

This post shows an example of a reaction mix purification requiring ELS detection.

Small Molecules and Synthetic Therapeutics

In this blog post we show how adding a base can reduce peptide loss over the course of your synthesis.

Small Molecules and Synthetic Therapeutics

This post highlights the benefits provided by various dry load media.

Small Molecules and Synthetic Therapeutics

This is a troubleshooting post discussing the causes and remedies for wavy chromatographic traces.

Small Molecules and Synthetic Therapeutics

This post describes how organic solvent choice impacts reversed phase separations.

Small Molecules and Synthetic Therapeutics

This post discusses two situations when the addition of a third solvent in a purification method addresses the issue.