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How much methanol can I use with my silica flash column?
Small Molecules and Synthetic Therapeutics
This post examines the true reason silica particles are often found if flash chromatography fractions.
The benefits of UV transparent chromatography solvents
Small Molecules and Synthetic Therapeutics
This post discusses the benefits of using UV transparent solvents for flash chromatography to improve compound detectability.
What is automated bead mill homogenization and when do I need it?
Clinical, Forensic and Doping Testing
What is bead mill homogenization and when do I use it?
When should amine-bonded columns be used for purification?
Small Molecules and Synthetic Therapeutics
This post highlights the ability of amine-bonded flash columns to alter selectivity of neutral compounds to improve their purification.
Can I make head-to-tail macrocycles on-resin?
Small Molecules and Synthetic Therapeutics
Cyclic peptides are becoming increasingly relevant, but how can we make them quicker and with higher crude purity? Here I talk about ...
What are good alternatives to shallow DCM/MeOH gradients?
Small Molecules and Synthetic Therapeutics
This post discusses two safer, environmentally friendly purification options to replace DCM - MeOH.
How do strongly basic analytes and SPE EVOLUTE®WCX work?
Clinical, Forensic and Doping Testing
How do strongly basic analytes and SPE work?
How do weakly acidic analytes and EVOLUTE®AX work?
Clinical, Forensic and Doping Testing
How do weakly acidic analytes and SPE work?
How to effectively use your flash system's diode-array detector
Small Molecules and Synthetic Therapeutics
This post highlights how a diode-array UV detector can provide important information about the purity of a collected fraction.
How do weakly basic analytes and SPE EVOLUTE®CX work?
Clinical, Forensic and Doping Testing
How do weakly basic analytes and SPE EVOLUTE CX work?
