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Using microwave heating to expedite your allyl ester or alloc deprotection
Small Molecules and Synthetic Therapeutics
Comparing conditions to expdite the selective removal of ally or alloc ester protecting groups using microwave heating.
Disulfide Rich Peptides - which order should the disulfide bonds be formed?
Small Molecules and Synthetic Therapeutics
When synthesizing peptides that contain multiple disulfide bonds you may consider the order in which those bonds are formed.
Room temperature allyl ester and alloc deprotections - what is the lifetime of palladium?
Small Molecules and Synthetic Therapeutics
Compare conditions for the selective removal of ally or alloc ester protecting groups at room temperature. Is it suitable for automation?
Using microwave heating for your stapled peptide synthesis
Small Molecules and Synthetic Therapeutics
Ring-closing metathesis has gained a lot of attention for use in peptide stapling strategies. Read more to learn how microwave heating can ...
How To: Measure and Optimize the Removal of MMT Protecting Groups
Small Molecules and Synthetic Therapeutics
Ensuring the complete removal of an orthogonal protecting group is the first step in optimizing on-resin secondary chemistry.
Optimizing the removal of an ACM protecting group
Small Molecules and Synthetic Therapeutics
Orthogonal protecting groups enable additional chemistry while peptides remain on the resin. Read more to learn how to remove Acm ...
Does amino acid concentration really matter during peptide synthesis?
Small Molecules and Synthetic Therapeutics
Concentration impacts the efficiency of a chemical reaction. Learn how increasing your amino acid concentration can improve your crude ...
Five Tips and Tricks for Success in Solid Phase Peptide Synthesis
Small Molecules and Synthetic Therapeutics
Read more for a short list of helpful tips and tricks to improve your peptide synthesis yield and purity.
How to purify synthetic peptides - what are the options?
Small Molecules and Synthetic Therapeutics
Synthetic peptides are often purified using RP-HPLC. Read more to learn how RP-flash chromatography could serve as an alternative.
Peptide Synthesis - What do you need to get started?
Small Molecules and Synthetic Therapeutics
Bringing peptide synthesis in-house requires some careful consideration. Read more to get a glimpse of what you'll need to get started.
