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Small Molecules and Synthetic Therapeutics

Ionization efficiency is critical for effective mass directed purification of peptides. Read more to learn how the carrier solvent impacts ...

Small Molecules and Synthetic Therapeutics

Resin choice is critical to ensure a successful peptide synthesis. Learn how swelling capacity and general hydrophilicity can help improve ...

Small Molecules and Synthetic Therapeutics

Resin choice can play a large role in successful peptide synthesis. Learn more about how resin substitution levels can impact your ...

Small Molecules and Synthetic Therapeutics

Double coupling costs not only time, but also extra reagents. Is it really necessary though? Read more to find out!

Small Molecules and Synthetic Therapeutics

Read about my first time trying out reversed phase flash chromatography for purifying my peptides. Spoiler alert: it works!

Small Molecules and Synthetic Therapeutics

Have you ever used a longer HPLC column to improve your separation? Read more to find out if this is a good strategy for flash ...

Small Molecules and Synthetic Therapeutics

Sometimes crude peptides are so dirty they require 2 purification passes. Read more to learn how connecting two different columns can ...

Small Molecules and Synthetic Therapeutics

It's clear that cyclizing peptides can, not only increase proteolytic stability, but may also increase cell permeability. As a result, ...

Small Molecules and Synthetic Therapeutics

Flash chromatography is often disregarded for peptide purification given its lower resolution. Read more to learn how alternative ...

Small Molecules and Synthetic Therapeutics

Learn about an optimized protocol for automated synthesis and ivDde protecting group removal using the Initiator+ Alstra™ peptide ...