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Small Molecules and Synthetic Therapeutics

Sometimes crude peptides are so dirty they require 2 purification passes. Read more to learn how connecting two different columns can ...

Small Molecules and Synthetic Therapeutics

It's clear that cyclizing peptides can, not only increase proteolytic stability, but may also increase cell permeability. As a result, ...

Small Molecules and Synthetic Therapeutics

Flash chromatography is often disregarded for peptide purification given its lower resolution. Read more to learn how alternative ...

Small Molecules and Synthetic Therapeutics

Learn about an optimized protocol for automated synthesis and ivDde protecting group removal using the Initiator+ Alstra™ peptide ...

Small Molecules and Synthetic Therapeutics

Comparing conditions to expdite the selective removal of ally or alloc ester protecting groups using microwave heating.

Small Molecules and Synthetic Therapeutics

When synthesizing peptides that contain multiple disulfide bonds you may consider the order in which those bonds are formed.

Small Molecules and Synthetic Therapeutics

Compare conditions for the selective removal of ally or alloc ester protecting groups at room temperature. Is it suitable for automation?

Small Molecules and Synthetic Therapeutics

Ring-closing metathesis has gained a lot of attention for use in peptide stapling strategies. Read more to learn how microwave heating can ...

Small Molecules and Synthetic Therapeutics

Ensuring the complete removal of an orthogonal protecting group is the first step in optimizing on-resin secondary chemistry.

Small Molecules and Synthetic Therapeutics

Orthogonal protecting groups enable additional chemistry while peptides remain on the resin. Read more to learn how to remove Acm ...