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Small Molecules and Synthetic Therapeutics

Cleaving peptides from resin is often a very fast reaction, however side chain protecting groups may require more time. What reaction time ...

Small Molecules and Synthetic Therapeutics

Reversed phase flash chromatography is growing in popularity as a strategy to purify crude peptide samples. Read more to how gradient ...

Small Molecules and Synthetic Therapeutics

Step gradients are often used in normal phase chromatography. Read more to learn how they can be used to also improve the purity of your ...

Small Molecules and Synthetic Therapeutics

Peptide purification with flash chromatography can be hampered by resolution losses. Read more to learn how a focused gradient can improve ...

Small Molecules and Synthetic Therapeutics

Ionization efficiency is critical for effective mass directed purification of peptides. Read more to learn how the carrier solvent impacts ...

Small Molecules and Synthetic Therapeutics

Resin choice is critical to ensure a successful peptide synthesis. Learn how swelling capacity and general hydrophilicity can help improve ...

Small Molecules and Synthetic Therapeutics

Resin choice can play a large role in successful peptide synthesis. Learn more about how resin substitution levels can impact your ...

Small Molecules and Synthetic Therapeutics

Double coupling costs not only time, but also extra reagents. Is it really necessary though? Read more to find out!

Small Molecules and Synthetic Therapeutics

Read about my first time trying out reversed phase flash chromatography for purifying my peptides. Spoiler alert: it works!

Small Molecules and Synthetic Therapeutics

Have you ever used a longer HPLC column to improve your separation? Read more to find out if this is a good strategy for flash ...