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Small Molecules and Synthetic Therapeutics

This is a troubleshooting post discussing the causes and remedies for wavy chromatographic traces.

Small Molecules and Synthetic Therapeutics

This post describes how organic solvent choice impacts reversed phase separations.

Small Molecules and Synthetic Therapeutics

This post discusses two situations when the addition of a third solvent in a purification method addresses the issue.

Biologics and Advanced Therapeutics

Learn how to choose between affinity tags for protein purification.

Small Molecules and Synthetic Therapeutics

Head-to-tail macrocycles remain difficult to synthesize on resin. Here is how C-terminal amino acid affects cyclization efficiency.

Small Molecules and Synthetic Therapeutics

This post highlights the time and solvent savings attainable with shorter linear gradients when maintaining gradient slope.

Small Molecules and Synthetic Therapeutics

Head-to-tail macrocycles remain difficult to synthesize on resin. Here is how the length and size of your pepetide can affect purity and ...

Small Molecules and Synthetic Therapeutics

This post highlights the time savings achievable using a step gradient in reversed phase flash chromatography.

Small Molecules and Synthetic Therapeutics

This post discusses how Biotage(R) Sfar C18 can be used to remove color from a reaction product.

Small Molecules and Synthetic Therapeutics

This post discusses the pros and cons of adding acid to a flash purification method.