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Techniques for disrupting protein binding in sample preparation
Clinical, Forensic and Doping Testing
This blog provide some tips about how to disrupt protein binding with sample preparation.
How to extract and analyze for ever-present contaminants of interest?
Clinical, Forensic and Doping Testing
How to develop extraction methods for persistent contaminants like nicotine, cotinine and tobacco related compounds and metabolites in ...
There and Square Again: A Frit Coverage Tale
Clinical, Forensic and Doping Testing
This blog post helps troubleshooting when you are not achieving complete frit coverage on the load of your sample.
Methods for a drug class or one large panel - what's the difference
Clinical, Forensic and Doping Testing
This blog describes advantages and disadvantages of the analysis of large panel of drugs that contains compounds from multiple drug classes.
Why should I filter my samples instead of doing dilute-and-shoot?
Clinical, Forensic and Doping Testing
This blog helps to understand the advantages of filtering your samples instead of dilute and shoot into your LC-MS/MS.
Synthetic Cannabinoids: how to extract them from whole blood?
Clinical, Forensic and Doping Testing
Rebecca Mastrovito from NMS has simplified the extraction of 12 novel synthetic cannabinoids using the Biotage ISOLUTE SLE+ cartridges.
Need good sources of reference for sample prep method development?
Clinical, Forensic and Doping Testing
This blog helps developing analytical methods providing list of reference websites for literature research related to analytes of interest.
Trying to develop a new method? How do I do a literature search?
Clinical, Forensic and Doping Testing
This blog provide tips on how to find reliable sources of information related to your analytes of interest before developing a new ...
What are the first steps to building a proper method?
Clinical, Forensic and Doping Testing
This blog post explains the how to ensure your analytes reach the low vacuum stage ion optics of the mass spectrometer in the greatest ...
What is crosstalk and how do I prevent it from contaminating my samples?
Clinical, Forensic and Doping Testing
The ACT Adapter reduces crosstalk of volatile drugs like amphetamines which can cause false positive results and re-extraction of clinical ...
