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How does my sample prep change between GC/MS and LC/MS/MS?
Clinical, Forensic and Doping Testing
This blog helps to understand hot to modify a sample preparation method optimized for LC/MS-MS analysis to better fit for a GC-MS analysis.
Determining the Optimal Sample Size for your Sorbent Bed Mass
Clinical, Forensic and Doping Testing
This blog helps you determine the optimal sample volume for a sorbent bed mass and helps you getting recovery for all compounds in your ...
Vacuum or positive pressure for processing samples: what's best?
Clinical, Forensic and Doping Testing
This blog discusses the advantages and disadvantages of vacuum pressure and positive pressure extraction.
Techniques for disrupting protein binding in sample preparation
Clinical, Forensic and Doping Testing
This blog provide some tips about how to disrupt protein binding with sample preparation.
How to extract and analyze for ever-present contaminants of interest?
Clinical, Forensic and Doping Testing
How to develop extraction methods for persistent contaminants like nicotine, cotinine and tobacco related compounds and metabolites in ...
There and Square Again: A Frit Coverage Tale
Clinical, Forensic and Doping Testing
This blog post helps troubleshooting when you are not achieving complete frit coverage on the load of your sample.
Methods for a drug class or one large panel - what's the difference
Clinical, Forensic and Doping Testing
This blog describes advantages and disadvantages of the analysis of large panel of drugs that contains compounds from multiple drug classes.
Why should I filter my samples instead of doing dilute-and-shoot?
Clinical, Forensic and Doping Testing
This blog helps to understand the advantages of filtering your samples instead of dilute and shoot into your LC-MS/MS.
Synthetic Cannabinoids: how to extract them from whole blood?
Clinical, Forensic and Doping Testing
Rebecca Mastrovito from NMS has simplified the extraction of 12 novel synthetic cannabinoids using the Biotage ISOLUTE SLE+ cartridges.
Need good sources of reference for sample prep method development?
Clinical, Forensic and Doping Testing
This blog helps developing analytical methods providing list of reference websites for literature research related to analytes of interest.
