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Small Molecules and Synthetic Therapeutics

This post shows how gradient slope optimization increases sample loading.

Small Molecules and Synthetic Therapeutics

This post describes various flash chromatography options available for targeted compound purification.

Small Molecules and Synthetic Therapeutics

This post discusses the benefits of purifying the full precipitated reaction mix vs. filtration, phase separation, redissolution and ...

Small Molecules and Synthetic Therapeutics

This post describes alternatives to DCM/Methanol for polar compound purification.

Small Molecules and Synthetic Therapeutics

This post compares the purification results of 5 dry load media vs. liquid loading.

Small Molecules and Synthetic Therapeutics

This post describes methodology to determine reversed-phase column loading capacity.

Small Molecules and Synthetic Therapeutics

Fractionating using multiple wavelengths simultaneously improves compound purity and yield compared to using one or two individual ...

Small Molecules and Synthetic Therapeutics

Removing a co-eluting impurity requires changing the purification method. Usually done with solvent change here we show the results of ...

Small Molecules and Synthetic Therapeutics

This post discusses preparation and use of flash chromatography dry loading.

Small Molecules and Synthetic Therapeutics

This post shows the utility of using a polar bonded phase (propyl NH2) to purify a mixture of polar compounds using water and acetonitrile.