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How does an acid pH modifier impact flash chromatography?
Small Molecules and Synthetic Therapeutics
This post discusses the pros and cons of adding acid to a flash purification method.
How can I overcome chromatography solvent detection interferences
Small Molecules and Synthetic Therapeutics
This post discusses the benefits of UV baseline correction with flash chromatography.
How much methanol can I use with my silica flash column?
Small Molecules and Synthetic Therapeutics
This post examines the true reason silica particles are often found if flash chromatography fractions.
The benefits of UV transparent chromatography solvents
Small Molecules and Synthetic Therapeutics
This post discusses the benefits of using UV transparent solvents for flash chromatography to improve compound detectability.
When should amine-bonded columns be used for purification?
Small Molecules and Synthetic Therapeutics
This post highlights the ability of amine-bonded flash columns to alter selectivity of neutral compounds to improve their purification.
What are good alternatives to shallow DCM/MeOH gradients?
Small Molecules and Synthetic Therapeutics
This post discusses two safer, environmentally friendly purification options to replace DCM - MeOH.
How to effectively use your flash system's diode-array detector
Small Molecules and Synthetic Therapeutics
This post highlights how a diode-array UV detector can provide important information about the purity of a collected fraction.
What can I use to purify polar reaction mixtures?
Small Molecules and Synthetic Therapeutics
This post shows how HILIC flash chromatography can generate separations of polar reaction mixtures better than normal-phase and ...
Do all silica flash columns provide the same results?
Small Molecules and Synthetic Therapeutics
This post aims to highlight selectivity and separation performance differences between three column brands.
How can I improve my liquid-liquid extraction process?
Small Molecules and Synthetic Therapeutics
This post highlights the efficiency and simplicity of Phase Separators for liquid-liquid extraction.
