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Small Molecules and Synthetic Therapeutics

This post discusses the benefits obtainable using dry loading vs. liquid loading.

Small Molecules and Synthetic Therapeutics

This post discusses whether a single or multiple fractionation wavelengths generate higher purity in greater amounts.

Small Molecules and Synthetic Therapeutics

This post discusses the benefits achievable when using a “high-performance" flash chromatography column.

Small Molecules and Synthetic Therapeutics

This post compares TLC-based gradients to a generic linear gradient to highlight the benefits TLC provides.

Small Molecules and Synthetic Therapeutics

This post discusses how ionizable compounds can be purified using reversed-phase flash column chromatography.

Small Molecules and Synthetic Therapeutics

This post discusses the relationship between column length and column diameter and their impact of chromatographic separations.

Small Molecules and Synthetic Therapeutics

This post discusses the 5 most important steps to successful flash chromatography.

Small Molecules and Synthetic Therapeutics

This blog describes the impact of particle size and flow on the loading capacity of a flash chromatography column.

Small Molecules and Synthetic Therapeutics

This post discussed the reasons TLC Rf values are important for flash column chromatography optimization.

Small Molecules and Synthetic Therapeutics

The post discusses the reasons dry silica columns get hot when solvent is introduced and the impact the generated heat has on the resulting ...