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Small Molecules and Synthetic Therapeutics

This post discusses the differences between RP flash and prep HPLC for compound purification.

Small Molecules and Synthetic Therapeutics

How do I purify my high boiling solvent reaction mixture using silica flash chromatography?

Small Molecules and Synthetic Therapeutics

This post discusses options to separate and purify compounds by flash chromatography when TLC conditions have not successfully worked.

Small Molecules and Synthetic Therapeutics

This post discusses the role that the organic solvent plays in reversed-phase separation performance.

Small Molecules and Synthetic Therapeutics

This post shows the benefits achievable when various solvents from different selectivity groups are used for method development using TLC.

Small Molecules and Synthetic Therapeutics

This post discusses the criterial for determining when to replace a used C18 column.

Small Molecules and Synthetic Therapeutics

This post shows the benefits obtained by purifying a reaction mixture using both normal- and reversed-phase flash chromatography.

Small Molecules and Synthetic Therapeutics

This post describes some troubleshooting and remedies for sample blowback after a liquid injection with a syringe.

Small Molecules and Synthetic Therapeutics

This post describes options available to remove contamination from both synthetic and natural products.

Small Molecules and Synthetic Therapeutics

This post discusses the challenges chemists can face when reusing silica columns.