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Small Molecules and Synthetic Therapeutics

ELSD is useful for finding molecules that have no chromophore during flash purification. Here we show how signal intensity can vary between ...

Small Molecules and Synthetic Therapeutics

In this blog post we show how adding a base can reduce peptide loss over the course of your synthesis.

Small Molecules and Synthetic Therapeutics

Head-to-tail macrocycles remain difficult to synthesize on resin. Here is how C-terminal amino acid affects cyclization efficiency.

Small Molecules and Synthetic Therapeutics

Head-to-tail macrocycles remain difficult to synthesize on resin. Here is how the length and size of your pepetide can affect purity and ...

Small Molecules and Synthetic Therapeutics

Head-to-tail macrocycles remain difficult to synthesize on resin. Here is how resin loading can affect purity and challenges associated ...

Small Molecules and Synthetic Therapeutics

Cyclic peptides are becoming increasingly relevant, but how can we make them quicker and with higher crude purity? Here I talk about ...