Biotage® Initiator+ Alstra™ is a fully automated microwave peptide synthesizer . With functionality such as Branches, Preactivation and “Edit on the fly”, and options for UV monitoring and MAOS (organic synthesis) capability, this instrument represents best-in-class systems for both small and large scale synthesis of peptides, peptoids, PNA and peptidomimetics.
“The Initiator+ SP Wave – I think it’s an amazing little beast. Semi-automated, which I think is ideal for an academic lab making lots of bizarre peptides and exotics on a day-to-day basis then it’s a fantastic instrument. You can make PNA and ours has worked amazingly well in terms of the purity of materials obtained” Prof Mark Bradley, School of Chemistry, University of Edinburgh
Biotage® MP-Cyanoborohydride is a macroporous polymer supported cyanoborohydride. It is a versatile reducing agent for the reductive amination of carbonyl compounds and reduction of imines. The reaction work-up protocol is greatly simplified by using the solid supported reagent. Specifically, compared with the small molecule sodium cyanoborohydride, it is reported that toxic cyanide is not released on reaction workup and therefore does not contaminate the product or pose a danger towards the user.
Biotage® MP-TMT is a macroporous polystyrene-bound trimercaptotriazine, a resin bound equivalent of 2,4,6-trimercaptotriazine (TMT). MP-TMT scavengers residual palladium from palladium catalyzed reactions and has also shown to remove other metals. The MP-base copolymer has been designed to yield a robust, low swelling material, which makes it ideal for restricted volume environments. Its unique pore structure provides greater access to the reactive sites resulting in faster reactions and higher recoveries.
Biotage® MP-Triacetoxyborohydride is a macroporous polystyrene-supported equivalent of tetraalkylammonium triacetoxyborohydride. Its primary applications in the reductive amination of aldehydes and ketones under neutral or mildly acidic reaction conditions. This resin was developed to perform in a manner similar to that of the well-established sodium triacetoxyborohydride, while simplifying reagent handling and product purification. Moreover, for many of these reactions, a scavenger resin may be added for one-pot purification of the product.
Biotage® MP-TsOH resin is a sulfonated macroporous polystyrene resin and has been optimized for use as a bound reagent or scavenger resin for the synthesis of small molecules.The sulfonic acid groups in MP-TsOH are readily accessible for removal of basic compounds (e.g. primary, secondary, and tertiary amines) by quaternary salt formation.
Biotage® PRESSURE+ manifolds deliver positive pressure, parallel processing for 96 well plates, 1 mL 3 mL and 6 mL column formats. The systems utilize a consistent, uniform flow of positive pressure to move both low and high viscosity liquids through SPE plates and columns.
Biotage® PS-Benzaldehyde resin is useful for removing nucleophiles from solution, including primary amines (selectively, even in the presence of secondary amines), hydrazines also carbon-based nucleophiles such as Meldrum’s acid and organometallics.
Biotage® PS-Carbodiimide is a neutral, bound carbodiimide that can be used for the synthesis of amides and esters. In general, PS-Carbodiimide was found to synthesize amides in high yield and purity without evidence of residual amine or carboxylic acid. Unreacted carboxylic acid, normally used in excess relative to the amine, remains bound to the resin during workup.
Biotage® PS-HOBt(HL) is a sulfonamide-linked, polymer supported equivalent of 1-hydroxybenzotriazole (HOBt). PS-HOBt(HL) is used to generate bound HOBt active esters, which can either be made and used in situ, or isolated and stored as stable intermediates for the synthesis of high purity amides.
Biotage® PS-PPh3-Pd resin is a polystyrene-supported equivalent of the small molecule catalyst tetrakis(triphenylphosphine) palladium(0) [Pd(Ph3P)4]. The primary application for the resin is as a catalyst for Suzuki-Miyaura coupling reactions between arylboronic acids and aryl halides. PS-PPh3-Pd may also have applications in other types of palladium-catalyzed processes in which Pd(Ph3P)4 is used. The Suzuki reaction is one of the most widely practiced coupling protocols for the preparation of symmetrical and unsymmetrical biaryl compounds. The resin was developed to perform in a manner similar to that of the well-established catalyst, while facilitating reagent handling and simplifying workup, product isolation, and removal of palladium.
Biotage® PS-TBD is a polymer-supported bicyclic guanidine moiety (1,5,7-triazabicyclo[4.4.0]dec-5-ene) base. PS-TBD applications include alkylation of phenols and amines; esterification of carboxylic acids using alkyl halides; alkylation of activated methylene compounds; de-halogenation of organic halides; high throughput synthesis of aryl triflates and aryl nonaflates, and the regioselective synthesis of lysophospholipids.
Biotage® PS-TEMPO is a novel polymer bound oxidant, based on a polystyrene bound, sulfonic ester linked 2,2,6,6-tetramethylpiperidine-1-oxyl species (PS-TEMPO),. It allows rapid and efficient access to often unstable ketone or aldehyde reactive species, and displays a visual indication of its oxidation state. The color change observed as the oxidation state of the reagent changes, can give an indication of the extent to which the reagent has been used. PS-TEMPO can be regenerated and reused for multiple oxidation reactions.
Biotage® PS-Triphenylphosphine is a powerful supported phosphine reagent for popular reactions such as Wittig, Mitsunobu, chlorination of acids and alcohols and the scavenging of alkyl halides. Unlike the small molecule reagent, the triphenylphosphine oxide by-product of reaction stays 100% resin bound, meaning that removal of product from phosphine oxide can be accomplished by simple low tech filtration techniques.