Biotage offers a range of products for reaction mixture work-up and preparation of organic extracts.
A complete set of tools to speed up traditional work flow processes and also enhance productivity and flexibility in the laboratory. These products range from solid supported reagents and scavengers, including the market leading Biotage Metal Scavengers, through to laboratory essentials, such as tubes, frits and separators, which can improve even the simplest of procedures.
The offer of work-up products spans over a range of techniques and also address throughput requirements from filtration, catch & release, and scavenging cartridges in organic synthesis workflows.
Catch & Release and Scavenging of Basic Compounds
ISOLUTE® SCX-2 is a silica-based media with a chemically bonded propylsulfonic acid functional group. It is used for the isolation of
a wide range of basic compounds using both catch & release and scavenging protocols. ISOLUTE SCX-2 is available packed into SPE
cartridges for flow-through. Using the catch & release approach, basic target compounds can be isolated from a range of reaction mixtures. ISOLUTE SCX-2 cartridges can be used to remove excess basic reagents, allowing neutral or acidic compounds to pass straight through to the collection vessel.
Catch & Release and Scavenging of Acidic Compounds
ISOLUTE® PE-AX is a silica-based sorbent with a chemically bonded quaternary amine functional group. It is used for the isolation of a wide range of acidic compounds using both catch & release and scavenging protocols. ISOLUTE PE-AX is available packed into SPE cartridges for flow-through. Using the catch &
release approach, acidic target compounds can be isolated from a range of reaction mixtures. ISOLUTE PE-AX cartridges can be
used in a scavenging mode to remove excess acidic reagents, allowing neutral or basic compounds to pass straight through to the collection vessel.
Simultaneous Scavenging of Basic and Acidic Compounds
ISOLUTE® PE-AX/SCX-2 is a silica-based media with chemically bonded propylsulfonic acid and quaternary amine functional groups. It is used for the isolation of a wide range of neutral compounds. ISOLUTE PE-AX/SCX-2 is available packed into SPE cartridges flow-through.
Concentration of Prep-LC Fractions Using Catch & Release
ISOLUTE® 103 is a hydroxylated polystyrene divinylbenzene co-polymer. The resin is used for the isolation of a wide range of compounds from prep LC fractions using catch & release protocol. The approach replaces the need for time-consuming evaporation of aqueous based fractions.
Synthetic organic chemistry is the genesis of new pharmaceutical and commercial chemical products. In short, it is based on the idea that two or more carbon-based compounds can be forced to react using heat, or other energy source, to create a new, novel product – but this we already know.
What are the steps most chemists follow to do this successfully?
The offer of work-up products spans over a range of techniques and also address throughput requirements from filtration, catch & release, and scavenging cartridges in organic synthesis workflows.
ISOLUTE® Phase Separators are used to separate aqueous and chlorinated solvents following liquid-liquid extraction. The proprietary filtration device allows the flow of the organic solvent but holds up the aqueous layer (for up to 24 hours).
Sodium sulfate is commonly used for drying water-immiscible organic solvents. ISOLUTE® Sodium Sulfate Drying Cartridges are a convenient alternative to using the bulk material. The male/female Luer design
allows the cartridge to be placed in-line after the main work-up cartridge. Alternatively, connect to an empty reservoir and load larger volumes of solvent. No need to use additional equipment. Just plug in and filter for instant results. The cartridge contains 2.5 g sodium sulfate and can remove up to 3.5 mL water.
Celite* cartridges are used as a filtration device for removal of “tar” and particulate materials (e.g. catalysts, as first- stage work-up following organic synthesis). The cartridges contain an inert Celite material, a modified diatomaceous earth, with an optimized particle-size distribution for flow-through processing. The cartridge holds up catalysts such as insoluble metal oxides and Pd/C, providing filtrates for subsequent work-up. The retention of the catalyst in a cartridge format minimizes safety issues and cross-contamination, a common problem when the catalyst is captured in an open filtration device such as a sintered funnel.
*Celite is a trademark owned by Johns-Manville Corporation
ISOLUTE® HM-N is a modified form of diatomaceous earth. The support has many uses in reaction work-up, including:
Synthetic organic chemistry is the genesis of new pharmaceutical and commercial chemical products. In short, it is based on the idea that two or more carbon-based compounds can be forced to react using heat, or other energy source, to create a new, novel product – but this we already know.
What are the steps most chemists follow to do this successfully?
Part No. | Description | Pack Size | List Price | |
---|---|---|---|---|
120-1151-D | 15 mL Frit Inserter | 5 | 64 USD | Add to quote/cart |
120-1151-J | 150 mL Frit Inserter | 1 | 30 USD | Add to quote/cart |
120-1151-E | 25 mL Frit Inserter | 1 | 29 USD | Add to quote/cart |
120-1151-F | 70 mL Frit Inserter | 1 | 29 USD | Add to quote/cart |
122-2100 | Biotage® FlashVac rack special | 1 | Add to quote/cart | |
122-0030 | Biotage® FlashVac silicone lid gasket | 1 | 38 USD | Add to quote/cart |
122-1030 | Biotage® FlashVac-10 19 mm rack | 1 | 272 USD | Add to quote/cart |
122-0049 | Biotage® FlashVac-10 and -20 glass tank | 1 | 314 USD | Add to quote/cart |
122-0044 | Biotage® FlashVac-10 and -20 rack handle | 1 | 22 USD | Add to quote/cart |
122-0047 | Biotage® FlashVac-10 lid | 1 | 1135 USD | Add to quote/cart |
122-1034 | Biotage® FlashVac-10 rack for 25 mm tubes | 1 | 250 USD | Add to quote/cart |
122-1036 | Biotage® FlashVac-10 Top/Mid PLATE, 25 mm | 1 | 108 USD | Add to quote/cart |
122-1019 | Biotage® FlashVac-10 with 19 mm 10 Position rack | 1 | 1574 USD | Add to quote/cart |
122-1025 | Biotage® FlashVac-10, 10 Ports with 25 mm rack | 1 | 1671 USD | Add to quote/cart |
122-2061 | Biotage® FlashVac-20 19 mm rack | 1 | 286 USD | Add to quote/cart |
122-2062 | Biotage® FlashVac-20 25mm rack | 1 | 272 USD | Add to quote/cart |
122-0048 | Biotage® FlashVac-20 lid, complete | 1 | 1135 USD | Add to quote/cart |
122-2019 | Biotage® FlashVac-20 with 19mm 20 position rack | 1 | 1574 USD | Add to quote/cart |
122-2025 | Biotage® FlashVac-20 with 25mm 10 position rack | 1 | 1574 USD | Add to quote/cart |
123-2016 | Biotage® Gravity rack with 16 mm collection tube rack | 1 | 687 USD | Add to quote/cart |
123-2019 | Biotage® Gravity rack with 19 mm collection tube rack | 1 | 687 USD | Add to quote/cart |
123-2119 | Biotage® Gravity Rack, TOP/MID plate, 19 mm | 1 | 114 USD | Add to quote/cart |
810-0100-D | Celite 545 1 g/15 mL | 20 | 114 USD | Add to quote/cart |
810-0100-C | Celite 545 1 g/6 mL | 30 | 137 USD | Add to quote/cart |
810-0100-CG | Celite 545 1 g/6 mL (Tabless) | 30 | 151 USD | Add to quote/cart |
810-1000-J | Celite 545 10 g/150 mL | 8 | 108 USD | Add to quote/cart |
810-0250-E | Celite 545 2.5 g/25 mL | 20 | 143 USD | Add to quote/cart |
810-0045-P01 | Celite 545 45 mg plate | 1 | 194 USD | Add to quote/cart |
120-1110 | Flash Luer Lock to Luer Adapters | 25 | 50 USD | Add to quote/cart |
103-0200-E | ISOLUTE® 103 2 g/25 mL | 20 | 715 USD | Add to quote/cart |
103-0020-BG | ISOLUTE® 103 200 mg/3 mL (Tabless) | 50 | 321 USD | Add to quote/cart |
103-0020-C | ISOLUTE® 103 200 mg/6 mL | 30 | 171 USD | Add to quote/cart |
103-0020-CG | ISOLUTE® 103 200 mg/6 mL (Tabless) | 30 | 187 USD | Add to quote/cart |
103-0500-E | ISOLUTE® 103 5 g/25 mL | 20 | 1721 USD | Add to quote/cart |
103-0050-C | ISOLUTE® 103 500 mg/6 mL | 30 | 329 USD | Add to quote/cart |
103-0050-CG | ISOLUTE® 103 500 mg/6 mL (Tabless) | 30 | 342 USD | Add to quote/cart |
180-0300-P01 | ISOLUTE® 96 Si-Thiol 300 mg plate | 1 | 451 USD | Add to quote/cart |
121-9650 | ISOLUTE® Array 24 | 1 | 199 USD | Add to quote/cart |
121-9660 | ISOLUTE® Array 24 Sealing Caps | 50 | 22 USD | Add to quote/cart |
120-1920-T | ISOLUTE® ARRAY Phase separator loose wells 2 mL | 100 | 143 USD | Add to quote/cart |
120-1920-TP | ISOLUTE® ARRAY PHASE SEPARATOR PLATE 2ML | 1 | 187 USD | Add to quote/cart |
420-5000-J | ISOLUTE® CN 50 g/150 mL | 8 | 990 USD | Add to quote/cart |
420-7000-J | ISOLUTE® CN 70 g/150 mL | 8 | 1281 USD | Add to quote/cart |
120-1106 | ISOLUTE® Column Adapter 150 mL columns | 5 | 215 USD | Add to quote/cart |
120-1215-D | ISOLUTE® Double Fritted Reservoir (SG), 15 mL 20 µm PE | 100 | 187 USD | Add to quote/cart |
120-1218-J | ISOLUTE® Double Fritted Reservoir (SG), 150 mL 20 µm PE | 25 | 187 USD | Add to quote/cart |
120-1217-F | ISOLUTE® Double Fritted Reservoir (SG), 70 mL 20 µm PE | 50 | 121 USD | Add to quote/cart |
120-1120-K | ISOLUTE® Filtration Column 50 mL | 25 | 199 USD | Add to quote/cart |
456-1000-F | ISOLUTE® FLASH SCX-2 10 g/70 mL | 16 | 455 USD | Add to quote/cart |
456-0100-C | ISOLUTE® FLASH SCX-2 1g/6ml | 30 | 180 USD | Add to quote/cart |
456-0200-D | ISOLUTE® FLASH SCX-2 2 g/15 mL | 20 | 180 USD | Add to quote/cart |
456-0200-DG | ISOLUTE® FLASH SCX-2 2 g/15 mL | 20 | 215 USD | Add to quote/cart |
456-2000-F | ISOLUTE® FLASH SCX-2 20 g/70 mL | 16 | 900 USD | Add to quote/cart |
456-2500-J | ISOLUTE® FLASH SCX-2 25 g/150 mL | 8 | 551 USD | Add to quote/cart |
456-0500-E | ISOLUTE® FLASH SCX-2 5 g/25 mL | 20 | 321 USD | Add to quote/cart |
456-5000-J | ISOLUTE® FLASH SCX-2 50 g/150 mL | 8 | 1086 USD | Add to quote/cart |
456-0050-B | ISOLUTE® FLASH SCX-2 500 mg/3 mL | 50 | 199 USD | Add to quote/cart |
456-7000-J | ISOLUTE® FLASH SCX-2 70 g/150 mL | 8 | 1513 USD | Add to quote/cart |
120-1365-D | ISOLUTE® Fritted Reservoir (SG), 15 mL 10 µm PE | 100 | 171 USD | Add to quote/cart |
120-1385-D | ISOLUTE® Fritted Reservoir (SG), 15 mL 10 µm PTFE | 100 | 269 USD | Add to quote/cart |
120-1115-D | ISOLUTE® Fritted Reservoir (SG), 15 mL 20 µm PE | 100 | 165 USD | Add to quote/cart |
120-1375-D | ISOLUTE® Fritted Reservoir (SG), 15 mL 20 µm PTFE | 100 | 301 USD | Add to quote/cart |
120-1369-J | ISOLUTE® Fritted Reservoir (SG), 150 mL 10 µm PE | 25 | 237 USD | Add to quote/cart |
120-1119-J | ISOLUTE® Fritted Reservoir (SG), 150 mL 20 µm PE | 25 | 187 USD | Add to quote/cart |
120-1366-E | ISOLUTE® Fritted Reservoir (SG), 25 mL 10 µm PE | 100 | 237 USD | Add to quote/cart |
120-1386-E | ISOLUTE® Fritted Reservoir (SG), 25 mL 10 µm PTFE | 100 | Add to quote/cart | |
120-1116-E | ISOLUTE® Fritted Reservoir (SG), 25 mL 20 µm PE | 100 | 199 USD | Add to quote/cart |
120-1376-E | ISOLUTE® Fritted Reservoir (SG), 25 mL 20 µm PTFE | 100 | 394 USD | Add to quote/cart |
120-1396-E | ISOLUTE® Fritted Reservoir (SG), 25 mL 5 µm PTFE | 100 | 400 USD | Add to quote/cart |
120-1367-F | ISOLUTE® Fritted Reservoir (SG), 70 mL 10 µm PE | 50 | 143 USD | Add to quote/cart |
120-1387-F | ISOLUTE® Fritted Reservoir (SG), 70 mL 10 µm PTFE | 50 | 256 USD | Add to quote/cart |
120-1118-F | ISOLUTE® Fritted Reservoir (SG), 70 mL 20 µm PE | 50 | 121 USD | Add to quote/cart |
120-1377-F | ISOLUTE® Fritted Reservoir (SG), 70 mL 20 µm PTFE | 50 | 329 USD | Add to quote/cart |
120-1397-F | ISOLUTE® Fritted Reservoir (SG), 70 mL 5 µm PTFE | 50 | 302 USD | Add to quote/cart |
801-1000-J | ISOLUTE® MgS04 10 g/150 mL | 8 | 105 USD | Add to quote/cart |
802-0250-D | ISOLUTE® NA2S04 2.5g/15 mL | 20 | 137 USD | Add to quote/cart |
503-1000-F | ISOLUTE® PE-AX 10 g/ 70 mL | 16 | 526 USD | Add to quote/cart |
503-0200-D | ISOLUTE® PE-AX 2 g/15 mL | 20 | 206 USD | Add to quote/cart |
503-2000-F | ISOLUTE® PE-AX 20 g/ 70 mL | 16 | 1057 USD | Add to quote/cart |
503-0500-E | ISOLUTE® PE-AX 5 g/25 mL | 20 | 321 USD | Add to quote/cart |
988-1000-F | ISOLUTE® PE-AX/SCX-2 10 /70 mL | 16 | 914 USD | Add to quote/cart |
988-2000-F | ISOLUTE® PE-AX/SCX-2 20 g/70 mL | 16 | 1766 USD | Add to quote/cart |
988-0500-E | ISOLUTE® PE-AX/SCX-2 5 g/25 mL | 20 | 592 USD | Add to quote/cart |
120-1906-D | ISOLUTE® Phase separator 15 mL | 100 | 230 USD | Add to quote/cart |
120-1909-J | ISOLUTE® Phase separator 150 mL | 25 | 243 USD | Add to quote/cart |
120-1903-B | ISOLUTE® Phase separator 3 mL | 100 | 187 USD | Add to quote/cart |
120-1903-BG | ISOLUTE® Phase separator 3 mL tabless | 100 | 194 USD | Add to quote/cart |
120-1905-CG | ISOLUTE® Phase separator 6 mL tabless | 100 | 250 USD | Add to quote/cart |
120-1907-E | ISOLUTE® Phase separator column 25 mL | 100 | 301 USD | Add to quote/cart |
120-1905-C | ISOLUTE® Phase separator column 6 mL | 100 | 230 USD | Add to quote/cart |
120-1910-P05 | ISOLUTE® Phase separator plate, fixed well | 5 | 450 USD | Add to quote/cart |
120-1910-P01 | ISOLUTE® PHASE SEPARATOR PLATE,FIXED WELL | 1 | 108 USD | Add to quote/cart |
120-1901-A | ISOLUTE® Phase separator, 1 mL | 100 | 157 USD | Add to quote/cart |
120-1908-F | ISOLUTE® Phase separator, 70 mL | 50 | 194 USD | Add to quote/cart |
120-1106-D | ISOLUTE® Reservoir (SG) 15 mL | 100 | 93 USD | Add to quote/cart |
120-1110-J | ISOLUTE® Reservoir (SG) 150 mL | 25 | 121 USD | Add to quote/cart |
120-1107-E | ISOLUTE® Reservoir (SG) 25 mL | 100 | 114 USD | Add to quote/cart |
120-1109-F | ISOLUTE® Reservoir (SG) 70 mL | 50 | 79 USD | Add to quote/cart |
532-1000-F | ISOLUTE® SCX-2 10 g/70 mL | 16 | 501 USD | Add to quote/cart |
532-0200-D | ISOLUTE® SCX-2 2 g/15 mL | 20 | 194 USD | Add to quote/cart |
FlashVac Sample Processing Manifolds are used to process the complete range of ISOLUTE work-up columns. The manifolds can be used for Catch & Release and scavenging SPE, filtration, and off-line sample loading prior to flash chromatography.
Biotage offers a range of accessories for use with filtration, Catch & Release, and scavenging SPE columns in organic synthesis work-up schemes.
Accessories include stop-cocks, luer tip caps, cartridge adaptors.
Biotage is the Global Go-To Separations Company, supporting customers from drug discovery and development through to diagnostics and analytical testing with intelligent and sustainable workflow solutions. Our expertise and top-tier separation solutions play a key role in streamlining our customers’ workflows and improving their outcomes. Headquartered in Sweden, Biotage operates globally with 700 employees, serving over 80 countries. Our company is listed on NASDAQ Stockholm (BIOT).
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