Committed to preserving our shared environment – further details available on request.
Can be used in processes in compliance with cGMP standards.
Manufacture of consumables is accredited by the world renowned British Standards Institute.
Flexible supply chains, back up manufacturing and warehousing ensures supply risk reduction
Can be used in processes in compliance with GLP standards.
Products which are scaleable from lab or development to process scale.
Long to indefinite product shelf life, reduced process risk.
Supports pharma guidelines for reducing elemental impurities in APIs.
Further extractable information provided on request.
Raw materials certified free of materials of human or animal origin.
Chemical substances used in our manufacturing process do not require registration.
Able to withstand mechanical stirring and heating under normal reaction conditions.
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Purification and Metal Scavenging
ISOLUTE® Si-Trisamine is a silica bound equivalent of a Trisamine base and can scavenge a variety of electrophiles, including aldehydes, acid chlorides, sulfonyl chlorides, isocyanates, isothiocyanates and heavy metal ions such as Mn2+, Fe3+, Co2+, Ni2+, Cu2+, Pb+2, Ru+2 and Zn2+. Si-Trisamine has a number of uses, it is a very powerful scavenger of transition metals and can also be used as a work-up tool to remove electrophiles or acids in either batch or flow-mode (cartridge) following traditional reflux heated or microwave synthesized reactions.
Heavy metals such as palladium, copper and tin are widely used in diverse transformations and their removal following organic synthesis has become a vital part of the API scale-up process. Si-Trisamine was applied successfully in the scavenging of palladium acetate, copper sulfate and nickel acetate from aqueous and organic solutions.
Scavenging of a 50 mg/50 mL THF/DMA solution of Pd(OAc)2 using a 500 mg/3 mL Si-Trisamine cartridge. Total residence time was 30 seconds, and the solution was allowed to flow through under gravity.
Scavenging of a 250 mg/5 mL aqueous solution of Ni(OAc)2.
Scavenging of a 500 mg aqueous solution of CuSO4.