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SPE Columns and Plates

Biotage sample preparation column size table

ISOLUTE® HCX-Q is a mixed-mode sorbent providing clean extracts for strongly basic compounds (e.g. quaternary amines) from complex biological fluid samples using a dual retention mechanism.


Part No. Description Product type Pack Size Price
986-0002-A 986-0002-A ISOLUTE® HCX-Q 25 mg/1 mL Consumables 100 Log in for price
986-0005-A 986-0005-A ISOLUTE® HCX-Q 50 mg/1 mL Consumables 100 Log in for price
986-0010-A 986-0010-A ISOLUTE® HCX-Q 100 mg/1 mL Consumables 100 Log in for price
986-0025-P01 986-0025-P01 ISOLUTE®-96 HCX-Q 25 mg Fixed Well Plate Consumables 1 Log in for price
986-0100-P01 986-0100-P01 ISOLUTE®-96 HCX-Q 100 mg Fixed Well Plate Consumables 1 Log in for price

Structure of ISOLUTE HCX-Q

ISOLUTE® HCX-Q combines non-polar (C8) and weak cation exchange retention  (COO-) mechanisms to isolate strongly basic analytes from complex aqueous matrices such as urine and plasma.

Analytes are initially retained by a non-polar retention mechanism, with inorganic salts, polar interferences such as phospholipids and large molecular weight peptides and proteins passing directly through the sorbent bed. The pH is then adjusted to allow an ion exchange retention mechanism to retain the analyte(s). Non-polar interferences are removed using an organic solvent or organic solvent/water wash. Analytes are then eluted in an extra clean fraction.

ISOLUTE HCX-Q is available in a wide range of SPE columns and 96-well plate formats.