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Biotage® MP-Trisamine

Powerful Scavenger for Acidic and Electrophilic Species

mp-trisamine

Biotage® MP-Trisamine is a macroporous polystyrene-bound scavenger, for electrophiles such as acid chlorides, sulfonyl chlorides, and isocyanates.

CONSUMABLES

Part No. Description Product type Pack Size Price
801397 Biotage® MP-Trisamine, 10 g Consumables 1 Log in for price
801398 Biotage® MP-Trisamine, 25 g Consumables 1 Log in for price
801399 Biotage® MP-Trisamine, 100 g Consumables 1 Log in for price
801400 Biotage® MP-Trisamine, 1 kg Consumables 1 Log in for price
801505 Biotage® MP-Trisamine, 3 g Consumables 1 Log in for price

Committed to preserving our shared environment – further details available on request.

Can be used in processes in compliance with cGMP standards.

Manufacture of consumables is accredited by the world renowned British Standards Institute.

Flexible supply chains, back up manufacturing and warehousing ensures supply risk reduction

Can be used in processes in compliance with GLP standards.

Products which are scaleable from lab or development to process scale.

Long to indefinite product shelf life, reduced process risk.

Supports pharma guidelines for reducing elemental impurities in APIs.

Further extractable information provided on request.

Raw materials certified free of materials of human or animal origin.

Chemical substances used in our manufacturing process do not require registration.

Able to withstand mechanical stirring and heating under normal reaction conditions.

Download the product note.

 

Background

Biotage® MP-Trisamine is a macroporous polystyrene-bound scavenger, for electrophiles such as acid chlorides, sulfonyl chlorides, and isocyanates. Resin-bound scavengers are added after a reaction is complete in order to quench and react selectively with excess reactants and/or reaction by-products.

MP-Trisamine is a highly cross-linked, robust, and low-swelling material, which makes it ideal for restricted volume environments (e.g. microwave vials, 96-well plates, etc.). Its unique pore structure provides greater access to the reactive sites without the need for solvent swelling, resulting in faster reactions and higher recoveries. The abrasion-resistant matrix has better handling characteristics and reduced transfer losses.

Trisamine Options and Metal Scavenging

Biotage supplies two bound Trisamines ligands. As well as MP-Trisamine, Biotage® Si-Trisamine is a powerful metal scavenger for transition metals such as Palladium, copper, zinc and iron. (see product note PPS372)

Representative Procedures

Scavenging by MP-Trisamine and PS-Trisamine in 1,2-Dichloroethane

The scavenging capability of MP-Trisamine was tested with a series of five electrophiles, present at an initial concentration of 0.5 M in dichloroethane (Table 1).

 

Electrophile

Resin

Equivalents

% Scavenged in 0.5 h

4-chlorobenzoyl chloride

PS-Trisamine

3.5

100

MP-Trisamine

3.5

100

2-phenylbutyryl chloride

PS-Trisamine

3.5

100

MP-Trisamine

3.5

100

2,6-dimethoxybenzoyl chloride

PS-Trisamine

3.5

100

MP-Trisamine

3.5

100

3-methoxyphenyl isocyanate

PS-Trisamine

3.0

92

MP-Trisamine

3.0

100

Benzene sulfonyl chloride

PS-Trisamine

4

100

MP-Trisamine

4

100

 

Under these conditions, four of the five electrophiles were scavenged within 0.5 h, using either of the two scavengers. The now defunct PS-Trisamine was unable to scavenge 3-methoxyphenyl isocyanate to completion in this time.

Summary

  • MP-Trisamine offers the following benefits:
  • Scavenges effectively in solvents that do not swell regular gel type cross-linked polystyrene
  • Limited swelling, so can be used where volume is restricted (e.g. 96 well plates, microwave vials)
  • For certain substrates, Biotage® MP-Trisamine offers more complete scavenging than traditional gel base Trisamine ligands.