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Biotage® ELSD-1080

Evaporative light-scattering detector

Biotage ELSD-1080

This product has been replaced by Biotage® ELSD-A120 Detector System

Check out the ELSD-A120 Product Page »

Biotage® ELSD (evaporative light-scattering detector) is a universal detector designed for use with Isolera™ flash purification systems when purifying organic compounds that are undetectable UV or visible light. Flash chromatography with detection and fractionation is now possible when purifying carbohydrates, steroids, lipids, terpenes and other UV-transparent compounds.

This product has been replaced by Biotage® ELSD-A120

Check out the ELSD-A120 Product Page »

Now replaced by Biotage® ELSD-A120 Detector System

Check out the ELSD-A120 Product Page »

 

 

Advanced Design

Organic compounds have different chemical and physical properties and they impact detection, even with an ELSD. Biotage ELSD-1080 provides intelligent method design which enables the chemist to independently set nebulizer and evaporator temperatures for a particular compound or compound class. Independent temperature control helps ensure that all compounds are detected.

Sub-ambient operation

Incorporated with the independent temperature control is the ability to evaporate solvents at temperatures as low as 10 °C. This is desirable when purifying highly volatile compounds.

How does ELSD work?

Sample eluting from a flash cartridge enters the ELSD where it is mixed with compressed nitrogen to nebulizer the sample (creates small droplets). The nebulizer is heated and begins to evaporate the solvent and the nitrogen pushes the sample into a heating chamber where the remaining solvent is evaporated leaving small sample particles in the nitrogen stream. While migrating through the evaporator, light is shone perpendicular to the “sample flight path” and a sensor measures how much light is coming through. Loss of light transmission is proportional to the amount of compound. This information is then relayed to the Isolera where it is then collected.

Compounds eluting from a flash cartridge enter the ELSD-1080 where they are mixed with nitrogen to nebulize the sample components creating small droplets. The nebulizer is heated and begins to evaporate the solvent and the nitrogen carries the sample into the Peltier heater where the remaining solvent is evaporated leaving small sample particles in the nitrogen stream. While migrating through the evaporator, light is shone perpendicular to the “sample flight path” and a sensor measures how many particles are present and triggering fraction collection.

  • Application Areas
  • Carbohydrates
  • Lipids
  • Steroid
  • Terpenes
  • Oils
  • Natural Products

Features

  • Flexibility – high sensitivity provides superb responses for all compounds, able to detect virtually any compound 
  • Sub-ambient operation – provides detection capability for highly volatile compounds with operation at temperatures as low as 10 °C up to 80 °C 
  • Reproducible - below 2% with reliable and accurate results 
  • Independent temperature controls – for both nebulizer and evaporator provides optimization capability for normal phase solvent systems 
  • Compact size – requires minimal bench space 
  • Compatible and portable – operates with other analytical HPLC systems