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urine webinar

Webinar Recording: Developing a Comprehensive Urine Pain Panel

28 March 2017

This webinar discusses considerations for developing robust sample preparation methods for acidic, basic and neutral drugs for pain management and compliance testing in hydrolyzed urine specimens. Method development strategies depending upon the drug analytes of interest are presented.

 

Watch the Webinar on Vimeo Here »

There has been increased interest in the clinical laboratory to develop comprehensive LC-MS/MS assays for urine drug testing, with fifty or more drugs and metabolites from multiple drug classes in a single method. These panels can increase throughput and improve laboratory efficiency, but also create many challenges. 

Key Learnings

  • Learn to develop better methods for large drug panels in urine based on the drugs of interest and their properties
  • Understand the effect of pH and logP on retention and recovery
  • Understand how to optimize enzyme and hydrolysis conditions
  • Learn when to choose supported liquid extraction (SLE), reverse-phase solid phase extraction (SPE), and ion exchange SPE

Who is this For?

Chemists and technologists, laboratory supervisors and managers, medical directors and R&D scientists in laboratories who develop, validate, or perform assays for urine drug testing.

This webinar was recorded on Thursday 9th March 2017

Presenter

Stephanie J. Marin, Senior Applications Chemist at Biotage.

Stephanie J. Marin received her Ph.D. in chemistry from Arizona State University. She has expertise in sample preparation, liquid chromatography, and mass spectrometry. She has over 10 years of experience developing and validating clinical assays from her tenure at the ARUP Institute for Clinical and Experimental Pathology. She is the author of over 30 peer reviewed publications and book chapters and over 80 abstracts presented at national meetings.

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Practical Considerations for LC/MS Method Development of a Comprehensive Urine Pain Panel