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Optimized Method for Extraction of Methylisothiazolinone

12 June 2015

This poster demonstrates the suitability of ISOLUTE® SLE+ for the rapid and reliable extraction of methylisothiazolinone (MI) from sunscreen at a relevant concentration, prior to GC/MS analysis. MI is extremely volatile and prone to evaporative losses. Initial method development focused on quantifying and reducing the amount of MI lost during the evaporation step. The optimized method offers high analyte recoveries with RSDs below 10%, demonstrating excellent chromatographic baseline and visual cleanliness. The BeadRuptor®24 offers greater homogeneity when mixing sunscreen matrix compared to manual vortex mixing.

MI is an antimicrobial preservative that is used in a variety of personal care products, such as sunscreens, lotions, cosmetics. MI is a cytotoxin and as a result there is concern because of sensitization and allergic reactions as well as cell and nerve damage. A percentage of the population is at risk from contact dermatitis when exposed to this compound at sufficient concentrations. From July 2015, the European Commission will adopt a ban of MI as an ingredient in leave-on cosmetic products.