Shopping Cart (Login required)
cannabinoid method

ISOLUTE® SLE+ Used in the Battle Against Emerging Synthetic Cannabinoids

08 July 2015

New designer drugs are constantly created by clandestine laboratories to circumvent drug monitoring programs. Chemists at the US National Institute on Drug Abuse (NIDA) have  developed a non-targeted LC-QTOF acquisition method for confirming 47 synthetic cannabinoid metabolites in human urine and used ISOLUTE® SLE+ columns to prepare their samples.

 

Targeted methods are of little use among laboratories testing for drugs of abuse when new synthetic cannabinoids are constantly emerging.  Scheidweiler et al. have developed an assay that is "...designed to be easily updated for the latest emerging NPS" (NPS=New Psychoactive Substance). "SLE recoveries were >76.2% for all metabolites and should accommodate new synthetic cannabinoids as new reference standards become available".

Read More

Nontargeted SWATH acquisition for identifying 47 synthetic cannabinoid metabolites in human urine by liquid chromatography-high-resolution tandem mass spectrometry Karl B. Scheidweiler, Michael J. Y. Jarvis, Marilyn A. Huestis »